American Journal of Obstetrics & Gynecology
Volume 203, Issue 1 , Pages 32.e1-32.e8 , July 2010

Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid

Presented in part at the 25th Annual Meeting of the Society for Maternal-Fetal Medicine, San Francisco, CA, Feb. 5-10, 2007.

  • Jane Hitti, MD

      Affiliations

    • Department of Obstetrics/Gynecology, University of Washington, Seattle, WA
    • ,
  • Jodi A. Lapidus, PhD

      Affiliations

    • Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR
    • ProteoGenix Inc., Beaverton, OR
    • ,
  • Xinfang Lu, MS

      Affiliations

    • ProteoGenix Inc., Beaverton, OR
    • ,
  • Ashok P. Reddy, PhD

      Affiliations

    • ProteoGenix Inc., Beaverton, OR
    • ,
  • Thomas Jacob, PhD

      Affiliations

    • ProteoGenix Inc., Beaverton, OR
    • ,
  • Surendra Dasari, PhD

      Affiliations

    • ProteoGenix Inc., Beaverton, OR
    • ,
  • David A. Eschenbach, MD

      Affiliations

    • Department of Obstetrics/Gynecology, University of Washington, Seattle, WA
    • ,
  • Michael G. Gravett, MD

      Affiliations

    • Department of Obstetrics/Gynecology, University of Washington, Seattle, WA
    • ProteoGenix Inc., Beaverton, OR
    • ,
  • Srinivasa R. Nagalla, MD

      Affiliations

    • Department of Pediatrics, Oregon Health & Science University, Portland, OR
    • ProteoGenix Inc., Beaverton, OR

Received 17 September 2009 ,Revised 15 January 2010 ,Accepted 18 March 2010.

  • Image Result

    Receiver-operator curve for the prediction of intraamniotic infection

    The red solid line shows the performance of alpha-1-acid glycoprotein alone; the black dotted line shows the performance of alpha-1

    Receiver-operator curve for the prediction of intraamniotic infection

    The red solid line shows the performance of alpha-1-acid glycoprotein alone; the black dotted line shows the performance of alpha-1-acid glycoprotein in combination with insulin-like growth factor binding protein-1 and fatty acid binding protein; and the green broken line shows the performance of alpha-1-acid glycoprotein in combination with insulin-like growth factor binding protein-1, calgranulin C, and cystatin A.

    Hitti. Noninvasive diagnosis of intraamniotic infection. Am J Obstet Gynecol 2010.

 Supported by National Institutes of Health Grant no. AI31871. These analyses were supported by ProteoGenix, Inc.

 Oregon Health & Science University and Drs Gravett, Nagalla, and Lapidus have a significant financial interest in ProteoGenix, Inc, which is a company that may have a commercial interest in the results of this research and technology. This potential conflict of interest has been reviewed, and a management plan has been approved by the Oregon Health & Science University Integrity Program Oversight Council and by the University of Washington Office of Technology Transfer. ProteoGenix provided the technical assays and proteomic analysis. Article preparation and submission was independent of the sponsor.

 Reprints not available from the authors.

 Cite this article as: Hitti J, Lapidus JA, Lu X, et al. Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid. Am J Obstet Gynecol 2010;203:32.e1-8.

PII: S0002-9378(10)00356-X

doi: 10.1016/j.ajog.2010.03.037

American Journal of Obstetrics & Gynecology
Volume 203, Issue 1 , Pages 32.e1-32.e8 , July 2010

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