American Journal of Obstetrics & Gynecology
Volume 203, Issue 1 , Pages 49.e1-49.e7, July 2010

Increased risk of adverse pregnancy outcomes among women affected by herpangina

  • Yi-Hua Chen, PhD

      Affiliations

    • Schools of Public Health, Taipei Medical University, Taipei, Taiwan
    • ,
  • Hsiu-Chen Lin, MD

      Affiliations

    • Department of Pediatric Infection, Taipei Medical University and Hospital, Taipei, Taiwan
    • ,
  • Herng-Ching Lin, PhD

      Affiliations

    • Health Care Administration, Taipei Medical University, Taipei, Taiwan
    • Corresponding Author InformationReprints: Herng-Ching Lin, PhD, School of Health Care Administration, Taipei Medical University, 250 Wu-Hsing St, Taipei 110, Taiwan

Received 5 August 2009; received in revised form 19 November 2009; accepted 10 February 2010. published online 26 April 2010.

Objective

This population-based study aimed to assess the relation between herpangina and adverse pregnancy outcomes: low birthweight (LBW), small for gestational age (SGA), and preterm delivery.

Study Design

A total of 242 pregnant women who had singleton births and who visited ambulatory care centers for the treatment of herpangina were assessed, together with 1936 matched women as a comparison group. Conditional logistic regression analyses were performed to examine the risk of LBW, preterm birth, and SGA for mothers with herpangina and unaffected mothers.

Results

Compared with pregnant women without herpangina, herpangina was associated with a 2.29- (95% confidence interval [CI], 1.42–3.69), 1.67- (95% CI, 1.04–2.68), and 1.63-fold (95% CI, 1.14–2.33) increased risk of having LBW, preterm, and SGA infants, respectively, after adjusting for family income and maternal and infant characteristics.

Conclusion

Our findings highlight a significant potential risk posed by herpangina, a usually mild disease, among pregnant women.

Key words: adverse pregnancy outcome, herpangina, pregnancy outcome

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 Cite this article as: Chen Y-H, Lin H-C, and Lin H-C. Increased risk of adverse pregnancy outcomes among women affected by herpangina. Am J Obstet Gynecol 2010;203:49.e1-7.

PII: S0002-9378(10)00238-3

doi:10.1016/j.ajog.2010.02.025

American Journal of Obstetrics & Gynecology
Volume 203, Issue 1 , Pages 49.e1-49.e7, July 2010

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