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American Journal of Obstetrics & Gynecology
Volume 202, Issue 5
, Pages 433.e1-433.e8
, May 2010
Patients with an asymptomatic short cervix (≤15 mm) have a high rate of subclinical intraamniotic inflammation: implications for patient counseling
References
- . Prediction of risk for preterm delivery by ultrasonographic measurement of cervical length. Am J Obstet Gynecol. 1990;163:859–867
- The length of the cervix and the risk of spontaneous premature delivery (National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network). N Engl J Med. 1996;334:567–572
- . Observations on the sonographic measurement of cervical length and risk of premature birth. J Maternal Fetal Med. 1999;8:17–19
- . Cervical length at 23 weeks of gestation: prediction of spontaneous preterm delivery. Ultrasound Obstet Gynecol. 1998;12:312–317
- Prediction of preterm delivery with transvaginal ultrasonography of the cervix in patients with high-risk pregnancies: does cerclage prevent prematurity?. Am J Obstet Gynecol. 1999;181:809–815
- Patients with an ultrasonographic cervical length less than or equal to 15 mm have nearly a 50% risk of early spontaneous preterm delivery. Am J Obstet Gynecol. 2000;182:1458–1467
- Can shortened midtrimester cervical length predict very early spontaneous preterm birth?. Am J Obstet Gynecol. 2004;191:298–303
- . Evaluation and validation of a new risk score (CLEOPATRA score) to predict the probability of premature delivery for patients with threatened preterm labor. Ultrasound Obstet Gynecol. 2005;26:699–706
- . Prediction of patient-specific risk of early preterm delivery using maternal history and sonographic measurement of cervical length: a population-based prospective study. Ultrasound Obstet Gynecol. 2006;27:362–367
- . Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med. 2007;357:462–469
- Vaginal progesterone is associated with a decrease in the risk of early preterm birth and an improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol. 2007;30:697–705
- . Progesterone for the prevention of preterm birth: a systematic review. Obstet Gynecol. 2008;112:127–134
- . Cervical length at 23 weeks of gestation: the value of Shirodkar suture for the short cervix. Ultrasound Obstet Gynecol. 1998;12:318–322
- . The short and funneling cervix: when to use cerclage?. Curr Opin Obstet Gynecol. 2005;17:574–578
- . Cerclage for short cervix on ultrasonography: meta-analysis of trials using individual patient-level data. Obstet Gynecol. 2005;106:181–189
- Multicenter randomized trial of cerclage for preterm birth prevention in high-risk women with shortened midtrimester cervical length. Am J Obstet Gynecol. 2009;201:375.e1–375.e8
- A sonographic short cervix as the only clinical manifestation of intra-amniotic infection. J Perinat Med. 2006;34:13–19
- . Short cervix on ultrasound: does indomethacin prevent preterm birth?. Am J Obstet Gynecol. 2006;195:809–813
- Does cervical cerclage prevent the preterm delivery in patients with a short cervix?. Am J Obstet Gynecol. 2001;184:1325–1329
- . Revisiting the short cervix detected by transvaginal ultrasound in the second trimester: why cerclage therapy may not help. Am J Obstet Gynecol. 2001;185:1098–1105
- . Cerclage for prevention of preterm birth in women with a short cervix found on transvaginal ultrasound examination: a randomized trial. Am J Obstet Gynecol. 2004;191:1311–1317
- . Cervical cerclage: a review of the evidence. Obstet Gynecol Surv. 2008;63:58–65
- . Prenatal medicine: the child is the father of the man. 1996. J Matern Fetal Neonatal Med. 2009;22:636–639
- . The role of cervical cerclage in obstetric practice: can the patient who could benefit from this procedure be identified?. Am J Obstet Gynecol. 2006;194:1–9
- Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2001;185:1130–1136
- Clinical significance of intra-amniotic inflammation in patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 2004;191:1339–1345
- . Is midtrimester short cervix a sign of intraamniotic inflammation?. Am J Obstet Gynecol. 2009;200:374–375
- . Human neutrophil collagenase. Methods Enzymol. 1995;248:431–449
- . Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients. J Clin Periodontol. 2000;27:366–369
- Value of amniotic fluid neutrophil collagenase concentrations in preterm premature rupture of membranes. Am J Obstet Gynecol. 2001;185:1143–1148
- . The relationship between placental histology and cervical ultrasonography in women at risk for pregnancy loss and spontaneous preterm birth. Am J Obstet Gynecol. 1999;181:793–797
- An elevated amniotic fluid matrix metalloproteinase-8 level at the time of mid-trimester genetic amniocentesis is a risk factor for spontaneous preterm delivery. Am J Obstet Gynecol. 2001;185:1162–1167
- The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis. Am J Obstet Gynecol. 2001;185:1156–1161
- . The frequency and significance of intraamniotic inflammation in patients with cervical insufficiency. Am J Obstet Gynecol. 2008;198:633–638
- . Inflammatory responses in the placenta and umbilical cord. Semin Fetal Neonatal Med. 2006;11:296–301
- Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. J Matern Fetal Neonatal Med. 2002;11:18–25
- The preterm parturition syndrome. BJOG. 2006;113(Suppl 3):17–42
- . The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007;25:21–39
- . Is amniotic fluid analysis the key to preterm labor? (A model using interleukin-6 for predicting rapid delivery). Am J Obstet Gynecol. 1998;179:172–178
- Amniotic fluid matrix metalloproteinase-8 in preterm labor with intact membranes. Am J Obstet Gynecol. 2001;185:1149–1155
- . Elevated amniotic fluid interleukin-6 levels at genetic amniocentesis predict subsequent pregnancy loss. Am J Obstet Gynecol. 1996;175:830–833
- . Elevated second-trimester amniotic fluid interleukin-6 levels predict preterm delivery. Am J Obstet Gynecol. 1998;178:546–550
- Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection. Am J Obstet Gynecol. 2000;183:94–99
- A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery. Am J Obstet Gynecol. 2006;195:1025–1030
- Comprehensive amniotic fluid cytokine profile evaluation in women with a short cervix: which cytokine(s) correlates best with outcome?. Am J Obstet Gynecol. 2009;201:276;e1-6
- Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol. 1989;161:817–824
- Infection and labor. VII. Microbial invasion of the amniotic cavity in spontaneous rupture of membranes at term. Am J Obstet Gynecol. 1992;166:129–133
- . Final results of the Cervical Incompetence Prevention Randomized Cerclage Trial (CIPRACT): therapeutic cerclage with bed rest versus bed rest alone. Am J Obstet Gynecol. 2001;185:1106–1112
- . Prevention of spontaneous preterm birth: the role of sonographic cervical length in identifying patients who may benefit from progesterone treatment. Ultrasound Obstet Gynecol. 2007;30:675–686
- . Gestational age at cervical length measurement and incidence of preterm birth. Obstet Gynecol. 2007;110:311–317
- The clinical significance of early (<20 weeks) versus late (20-24 weeks) detection of a sonographic short cervix in asymptomatic women. Ultrasound Obstet Gynecol. 2008;32:276
- . Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol Rev. 1995;59:143–169
- . The search for unrecognized pathogens. Science. 1999;284:1308–1310
- . Monitoring complex bacterial communities using culture-independent molecular techniques: application to soil environment. Res Microbiol. 2000;151:167–177
- Bacterial 16S rDNA polymerase chain reaction in the detection of intra-amniotic infection. Br J Obstet Gynaecol. 1996;103:664–669
- Broad-spectrum bacterial rDNA polymerase chain reaction assay for detecting amniotic fluid infection among women in premature labor. Clin Infect Dis. 1997;24:1228–1232
- Clinical implications of detection of Ureaplasma urealyticum in the amniotic cavity with the polymerase chain reaction. Am J Obstet Gynecol. 2000;183:1130–1137
- The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor. Am J Obstet Gynecol. 2003;189:919–924
- . Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature labor. Am J Perinatol. 2004;21:319–323
- Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. PloS One. 2008;3:e3056
- Prevalence and diversity of microbes in the amniotic fluid, the fetal inflammatory response, and pregnancy outcome in women with preterm pre-labor rupture of membranes. Am J Reprod Immunol. 2010;Mar 21 [Epub ahead of print]
- . Amniotic fluid interleukin-6: correlation with upper genital tract microbial colonization and gestational age in women delivered after spontaneous labor versus indicated delivery. Am J Obstet Gynecol. 1995;173:606–612
- The prevalence and clinical significance of amniotic fluid ‘sludge’ in patients with preterm labor and intact membranes. Ultrasound Obstet Gynecol. 2005;25:346–352
- Intra-amniotic sludge, short cervix, and risk of preterm delivery. J Obstet Gynaecol Can. 2006;28:198–202
- Clinical significance of the presence of amniotic fluid ‘sludge’ in asymptomatic patients at high risk for spontaneous preterm delivery. Ultrasound Obstet Gynecol. 2007;30:706–714
- What is amniotic fluid ‘sludge’?. Ultrasound Obstet Gynecol. 2007;30:793–798
- Detection of a microbial biofilm in intraamniotic infection. Am J Obstet Gynecol. 2008;198:135.e1–135.e5
- . The danger model: a renewed sense of self. Science. 2002;296:301–305
- . The inflammasome: first line of the immune response to cell stress. Cell. 2006;126:659–662
- . Sensing pathogens and danger signals by the inflammasome. Curr Opin Immunol. 2009;21:10–16
- “The Inflammasone” in human parturition. Reprod Sci. 2007;14(supp):59A
- Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition. J Matern Fetal Neonatal Med. 2008;21:605–616
Cite this article as: Vaisbuch E, Hassan SS, Mazaki-Tovi S, et al. Patients with an asymptomatic short cervix (≤15 mm) have a high rate of subclinical intraamniotic inflammation: implications for patient counseling. Am J Obstet Gynecol 2010;202:433.e1-8.
This study was supported in part by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services.
PII: S0002-9378(10)00212-7
doi: 10.1016/j.ajog.2010.02.007
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American Journal of Obstetrics & Gynecology
Volume 202, Issue 5
, Pages 433.e1-433.e8
, May 2010
