American Journal of Obstetrics & Gynecology
Volume 202, Issue 3 , Pages 239.e1-239.e10, March 2010

An international trial of antioxidants in the prevention of preeclampsia (INTAPP)

Presented orally at the 30th Annual Meeting of the Society for Maternal-Fetal Medicine, Chicago, IL, Feb. 1-6, 2010.

  • Hairong Xu, MD, MSc

      Affiliations

    • Department of Obstetrics and Gynecology, Hôpital Ste-Justine, Université de Montréal, Montreal, QC, Canada
    • ,
  • Ricardo Perez-Cuevas, MD, PhD

      Affiliations

    • Instituto Mexicano del Seguro Sosial, Mexico City, Mexico
    • ,
  • Xu Xiong, MD, PhD

      Affiliations

    • Tulane University, New Orleans, LA
    • ,
  • Hortensia Reyes, MD, PhD

      Affiliations

    • National Institute of Public Health, Cuernavaca, Mexico
    • ,
  • Chantal Roy, MSc

      Affiliations

    • Department of Obstetrics and Gynecology, Hôpital Ste-Justine, Université de Montréal, Montreal, QC, Canada
    • ,
  • Pierre Julien, PhD

      Affiliations

    • Centre de Recherche du CHUQ, Quebec, QC, Canada
    • ,
  • Graeme Smith, MD, PhD

      Affiliations

    • Kingston General Hospital, Kingston, ON, Canada
    • ,
  • Peter von Dadelszen, MBChB, DPhil

      Affiliations

    • Children's and Women's Health Centre of BC, Vancouver, BC, Canada
    • ,
  • Line Leduc, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Hôpital Ste-Justine, Université de Montréal, Montreal, QC, Canada
    • ,
  • François Audibert, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Hôpital Ste-Justine, Université de Montréal, Montreal, QC, Canada
    • ,
  • Jean-Marie Moutquin, MD, MSc

      Affiliations

    • CHUS/Hôpital Fleurimont, Sherbrooke, QC, Canada
    • ,
  • Bruno Piedboeuf, MD

      Affiliations

    • Centre de Recherche du CHUQ, Quebec, QC, Canada
    • ,
  • Bryna Shatenstein, PhD

      Affiliations

    • Institut Universitaire de Gériatrie, Montreal, QC, Canada
    • ,
  • Socorro Parra-Cabrera, PhD

      Affiliations

    • National Institute of Public Health, Cuernavaca, Mexico
    • ,
  • Pierre Choquette, MD

      Affiliations

    • Cité de la santé, Laval, QC, Canada
    • ,
  • Stephanie Winsor, MD

      Affiliations

    • McMaster Medical Centre, Hamilton, ON, Canada
    • ,
  • Stephen Wood, MD

      Affiliations

    • Foothills Hospital, Calgary, AB, Canada
    • ,
  • Alice Benjamin, MD

      Affiliations

    • Royal-Victoria Hospital, Montreal, QC, Canada
    • ,
  • Mark Walker, MD, MSc

      Affiliations

    • Ottawa Hospital, Ottawa, ON, Canada
    • ,
  • Michael Helewa, MD

      Affiliations

    • St-Boniface General Hospital, Winnipeg, MB, Canada
    • ,
  • Johanne Dubé, MD

      Affiliations

    • CHUM, Hôpital St-Luc, Montreal, QC, Canada
    • ,
  • Georges Tawagi, MD

      Affiliations

    • Ottawa Hospital, Ottawa, ON, Canada
    • ,
  • Gareth Seaward, MD

      Affiliations

    • Mount Sinaï Hospital, Toronto, ON, Canada
    • ,
  • Arne Ohlsson, MD, MSc

      Affiliations

    • Mount Sinaï Hospital, Toronto, ON, Canada
    • ,
  • Laura A. Magee, MD, MSc

      Affiliations

    • Children's and Women's Health Centre of BC, Vancouver, BC, Canada
    • ,
  • Femi Olatunbosun, MD

      Affiliations

    • Royal University Hospital, Saskatoon, SK, Canada
    • ,
  • Robert Gratton, MD, MSc

      Affiliations

    • St Joseph's Health Centre, London, ON, Canada
    • ,
  • Roberta Shear, MD

      Affiliations

    • Jewish General Hospital, Montreal, QC, Canada
    • ,
  • Nestor Demianczuk, MD

      Affiliations

    • Royal-Alexandra Hospital, Edmonton, AB, Canada
    • ,
  • Jean-Paul Collet, MD, PhD

      Affiliations

    • Children's and Women's Health Centre of BC, Vancouver, BC, Canada
    • ,
  • Shuqin Wei, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Hôpital Ste-Justine, Université de Montréal, Montreal, QC, Canada
    • ,
  • William D. Fraser, MD, MSc; and

      Affiliations

    • Department of Obstetrics and Gynecology, Hôpital Ste-Justine, Université de Montréal, Montreal, QC, Canada
    • Corresponding Author InformationReprints: William D. Fraser, MD, MSc, Department of Obstetrics and Gynecology, Université de Montréal, 3175 Chemin de la Côte Sainte-Catherine, Montreal (Quebec) Canada H3T 1C5
    • ,
  • INTAPP study group

Received 21 November 2009; received in revised form 13 January 2010; accepted 19 January 2010.

Objective

We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women.

Study Design

In a multicenter randomized controlled trial, women were stratified by the risk status and assigned to daily treatment (1 g vitamin C and 400 IU vitamin E) or placebo. The primary outcome was GH and its adverse conditions.

Results

Of the 2647 women randomized, 2363 were included in the analysis. There was no difference in the risk of GH and its adverse conditions between groups (relative risk, 0.99; 95% confidence interval, 0.78–1.26). However, vitamins C and E increased the risk of fetal loss or perinatal death (nonprespecified) as well as preterm prelabor rupture of membranes.

Conclusion

Vitamin C and E supplementation did not reduce the rate of preeclampsia or GH, but increased the risk of fetal loss or perinatal death and preterm prelabor rupture of membranes.

Key words: preeclampsia, randomized controlled trial, vitamins C and E

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 Sponsored by the Canadian Institutes of Health Research.

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 Cite this article as: Xu H, Perez-Cuevas R, Xiong X, et al. An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am J Obstet Gynecol 2010;202:239.e1-10.

PII: S0002-9378(10)00080-3

doi:10.1016/j.ajog.2010.01.050

Refers to article:

  • Cross-reference Latest research from the 2010 meeting of the Society for Maternal-Fetal Medicine

    Jay D. Iams
    American Journal of Obstetrics & Gynecology March 2010 (Vol. 202, Issue 3, Page 207)

American Journal of Obstetrics & Gynecology
Volume 202, Issue 3 , Pages 239.e1-239.e10, March 2010

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