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American Journal of Obstetrics & Gynecology
Volume 202, Issue 5
, Pages 464.e1-464.e6
, May 2010
Nicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in an in vitro model of preeclamptic vascular endothelium: a possible therapeutic role of nicotinic acetylcholine receptor (nAChR) agonists for preeclampsia
References
- . Pre-eclampsia. Lancet. 2005;365:785–799
- . Latest advances in understanding preeclampsia. Science. 2005;308:1592–1594
- . The pathological response of the vessels of the placental bed to hypertensive pregnancy. J Pathol Bacteriol. 1967;93:581–592
- . Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998;16:5–15
- . Angiogenic factors in the pathogenesis of preeclampsia. Curr Top Dev Biol. 2005;71:297–312
- Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672–683
- Urinary placental growth factor and risk of preeclampsia. JAMA. 2005;293:77–85
- Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006;355:992–1005
- Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia. J Matern Fetal Neonatal Med. 2005;17:3–18
- Maternal serum sFlt1 concentration is an early and reliable predictive marker of preeclampsia. Clin Chem. 2004;50:1702–1703
- Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649–658
- Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J Clin Endocrinol Metab. 2003;88:2348–2351
- Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Am J Obstet Gynecol. 2004;190:1541–1547
- Maternal serum soluble fms-like tyrosine kinase 1 concentrations are not increased in early pregnancy and decrease more slowly postpartum in women who develop preeclampsia. Am J Obstet Gynecol. 2005;193:185–191
- . Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem Biophys Res Commun. 1996;226:324–328
- Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006;12:642–649
- A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ Res. 2005;96:684–692
- . Angiogenic imbalance in the pathophysiology of preeclampsia: newer insights. Semin Nephrol. 2004;24:548–556
- . Cigarette smoking during pregnancy and risk of preeclampsia: a systematic review. Am J Obstet Gynecol. 1999;181:1026–1035
- . Smoking in pregnancy revisited: findings from a large population-based study. Am J Obstet Gynecol. 2005;192:1856–1862
- . Cigarette smoke exposure and angiogenic factors in pregnancy and preeclampsia. Am J Hypertens. 2008;21:943–947
- Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med. 2001;7:833–839
- . Angiogenesis and the role of the endothelial nicotinic acetylcholine receptor. Life Sciences. 2007;80:2347–2351
- . Cigarette smoking pharmacokinetics and its relationship to smoking behavior. Clin Pharmacokinet. 1984;9:435–449
- . Cigarette smoking: carboxyhemoglobin, plasman nicotine, cotinine and thiocyanate vs self-reported smoking data and cardiovascular disease. J Chronic Dis. 1983;36:439–449
- . Clearing the smoke on nicotine and angiogenesis. Nat Med. 2001;7:775–777
- . Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells. Am J Pathol. 2002;160:413–418
- . A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest. 2002;110:527–536
- . In vitro assays of angiogenesis for assessment of angiogenic and anti-angiogenic agents. Microvasc Res. 2007;74:172–183
- Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells. Atherosclerosis. 2003;170:229–236
- Expression of vascular endothelial growth factor in human umbilical vein endothelial cells stimulated with interleukin-1alpha—an autocrine regulation of angiogenesis and inflammatory reactions. Thromb Haemost. 2000;83:949–955
- Nicotine patch use in pregnant smokers: nicotine and cotinine levels and fetal effects. Am J Obset Gynecol. 1999;181:736–743
- . Nicotine patches for pregnant smokers: a randomized controlled study. Obstet Gynecol. 2000;96:967–971
- Nicotine gum for pregnant smokers: a randomized controlled trial. Obstet Gynecol. 2008;112:859–867
- . Behavioral and neural consequences of prenatal exposure to nicotine. J Am Acad Child Adolesc Psychiatry. 2001;40:630–641
- . The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation. Br J Pathol. 2007;151:915–929
- Carbon monoxide decreases perfusion pressure in isolated human placenta. Placenta. 2002;23:563–569
- . Adverse pregnancy outcomes in snuff users. Am J Obstet Gynecol. 2003;189:939–943
- . Carbon monoxide inhibits hypoxia/reoxygenation-induced apoptosis and secondary necrosis in syncytiotrophoblast. Am J Pathol. 2006;169:774–783
- End-tidal carbon monoxide measurements in women with pregnancy-induced hypertension and preeclampsia. Am J Obstet Gynecol. 2000;183:900–903
- End tidal carbon monoxide levels are lower in women with gestational hypertension and pre-eclampsia. J Perinatol. 2004;24:213–217
- Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1. Circulation. 2007;115:1789–1797
- . Nicotine inhibits cytokine production by placenta cells via NFkappaB: potential role in pregnancy-induced hypertension. Mol Med. 2007;13:576–583
- . Placental angiogenesis markers sFlt-1 and PlGF: response to cigarette smoke. Am J Obstet Gynecol. 2007;197:363.e1–363.e5
- . Antiangiogenic effect of soluble vascular endothelial growth factor receptor-1 in placental angiogenesis. Endothelium. 2005;12:89–95
- . The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia. Reprod Biol Endocrinol. 2004;2:53
- Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002;160:1405–1423
- . Role of placenta growth factor (PIGF) in human extravillous trophoblast proliferation, migration and invasiveness. Placenta. 1998;19:465–473
- . Signal transduction and biological function of placenta growth factor in primary human trophoblast. Biol Reprod. 1999;60:887–892
- Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003;421:384–388
- Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med. 2004;10:1216–1221
- Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med. 2005;201:1113–1123
- . Effects of nicotine on intercellular adhesion molecule expression in endothelial cells and integrin expression in neutrophils in vitro. Am J Obstet Gynecol. 2002;186:551–556
- . Inflammation and pre-eclampsia. Semin Fetal Neonatal Med. 2006;11:309–316
Cite this article as: Mimura K, Tomimatsu T, Sharentuya N, et al. Nicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in an in vitro model of preeclamptic vascular endothelium: a possible therapeutic role of nicotinic acetylcholine receptor (nAChR) agonists for preeclampsia. Am J Obstet Gynecol 2010;202:464.e1-6.
Reprints not available from the authors.
This study was supported by Grant in Aid for Scientific Research (nos. 19390429, 19599012) from the Ministry of Education, Science, and Culture of Japan.
PII: S0002-9378(10)00067-0
doi: 10.1016/j.ajog.2010.01.037
© 2010 Mosby, Inc. All rights reserved.
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American Journal of Obstetrics & Gynecology
Volume 202, Issue 5
, Pages 464.e1-464.e6
, May 2010
