American Journal of Obstetrics & Gynecology
Volume 202, Issue 5 , Pages 505.e1-505.e5 , May 2010

Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?

Presented at the 30th Annual Scientific Meeting of the American Urogynecologic Society, Hollywood, FL, Sept. 23-26, 2009.

  • Chen Chen, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA
    • ,
  • Lori D. Hill, BS

      Affiliations

    • Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA
    • ,
  • Christine M. Schubert, PhD

      Affiliations

    • Department of Biostatistics, Virginia Commonwealth University Medical Center, Richmond, VA
    • ,
  • Jerome F. Strauss III, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA
    • ,
  • Catherine A. Matthews, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA

Received 3 August 2009 ,Revised 21 October 2009 ,Accepted 12 January 2010.

References 

  1. Chiaffarino F, Chatenoud L, Dindelli M, et al. Reproductive factors, family history, occupation and risk of urogenital prolapse. Eur J Obstet Gynecol Reprod Biol. 1999;82:63–67
  2. Mant J, Painter R, Vessey M. Epidemiology of genital prolapse: observations from the Oxford family planning association study. Br J Obstet Gynaecol. 1997;104:579–585
  3. Weber AM, Richter HE. Pelvic organ prolapse. Obstet Gynecol. 2005;106:615–634
  4. Bump RC, Norton PA. Epidemiology and natural history of pelvic floor dysfunction. Obstet Gynecol Clin North Am. 1998;25:723–746
  5. Nygaard I, Bradley C, Brandt D. Pelvic organ prolapse in older women: prevalence and risk factors. Obstet Gynecol. 2004;104:489–497
  6. Dannecker C, Anthuber C. The effects of childbirth on the pelvic floor. J Perinat Med. 2000;28:175–184
  7. Gill EJ, Hurt WG. Pathophysiology of pelvic organ prolapse. Obstet Gynecol Clin North Am. 1998;25:757–769
  8. Hendrix SL, Clark A, Nygaard I, et al. Pelvic organ prolapse in the women's health initiative: gravity and gravidity. Am J Obstet Gynecol. 2002;186:1160–1166
  9. Buchsbaum GM, Duecy EE, Kerr LA, et al. Pelvic organ prolapse in nulliparous women and their parous sisters. Obstet Gynecol. 2006;108:1388–1393
  10. Jack GS, Nikolova G, Vilain E, Raz S, Rodriguez LV. Familial transmission of genitovaginal prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2006;17:498–501
  11. Allen-Brady K, Norton PA, Farnham JM, Teerlink C, Cannon-Albright LA. Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21. Am J Hum Genet. 2009;84:678–682
  12. Swift S, Woodman P, O'Boyle A, et al. Pelvic organ support study (POSST): the distribution, clinical definition, and epidemiologic condition of pelvic organ support defects. Am J Obstet Gynecol. 2005;192:795–806
  13. Sewell CA, Chang E, Sultana CJ. Prevalence of genital prolapse in 3 ethnic groups. J Reprod Med. 2007;52:769–773
  14. Nikolova G, Lee H, Berkovitz S, et al. Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. Hum Genet. 2007;120:847–856
  15. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–575
  16. Ferrell G, Lu M, Stoddard P, et al. A single nucleotide polymorphism in the promoter of the LOXL1 gene and its relationship to pelvic organ prolapse and preterm premature rupture of membranes. Reprod Sci. 2009;16:438–446
  17. DeLancey JO, Kane Low L, Miller JM, Patel DA, Tumbarello JA. Graphic integration of causal factors of pelvic floor disorders: an integrated life span model. Am J Obstet Gynecol. 2008;199:610.e1–610.e5

 This research was supported by National Institutes of Health Grant P60 MD002256. Ms Hill is supported by the Virginia Commonwealth University Physician-Scientist Training Program.

 Cite this article as: Chen C, Hill LD, Schubert CM, et al. Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse? Am J Obstet Gynecol 2010;202:505.e1-5.

 Reprints not available from the authors.

PII: S0002-9378(10)00025-6

doi: 10.1016/j.ajog.2010.01.014

American Journal of Obstetrics & Gynecology
Volume 202, Issue 5 , Pages 505.e1-505.e5 , May 2010

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