Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?
Presented at the 30th Annual Scientific Meeting of the American Urogynecologic Society, Hollywood, FL, Sept. 23-26, 2009.
Received 3 August 2009; received in revised form 21 October 2009; accepted 12 January 2010. published online 11 March 2010.
Objective
We sought to determine allele frequencies of 3 LAMC1 single nucleotide polymorphisms (SNPs) in Caucasian and African American (AA) women with stage > II pelvic organ prolapse (POP) (cases) and in ethnicity-matched controls with stage < II POP. We also sought to determine if LAMC1 is associated with POP within ethnic groups.
Study Design
Allelic discrimination was performed for LAMC1 SNPs rs10911193 (C/T), rs20563 (A/G), and rs20558 (T/C). SNP and haplotype-specific tests were used to examine associations among POP, ethnicity, and LAMC1.
Results
In all, 411 women were enrolled. Significant differences in allele and haplotype frequencies existed among AAs and Caucasians: rs10911193 “T” (P = .0014); rs20563 “G” (P < .0001); rs20558 “C” (P < .0001); rs20563, rs20558 “GC” (P < .0001); and rs20563, rs20558 “AT” (P < .0001). No significant associations between POP and LAMC1 SNPs or haplotypes were found within ethnicities.
Conclusion
While significant differences were identified between AA and Caucasian women, no associations were found between any LAMC1 gene variant and advanced POP.
aDepartment of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA
bDepartment of Biostatistics, Virginia Commonwealth University Medical Center, Richmond, VA
This research was supported by National Institutes of Health Grant P60 MD002256. Ms Hill is supported by the Virginia Commonwealth University Physician-Scientist Training Program.
Cite this article as: Chen C, Hill LD, Schubert CM, et al. Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse? Am J Obstet Gynecol 2010;202:505.e1-5.
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