American Journal of Obstetrics & Gynecology
Volume 202, Issue 6 , Pages 561.e1-561.e5, June 2010

Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction

Presented at the 29th Annual Scientific Meeting of the Society for Maternal-Fetal Medicine, San Diego, CA, Jan. 26-31, 2009.

  • Michal Kovo, MD, PhD

      Affiliations

    • Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel
    • Corresponding Author InformationReprints: Michal Kovo, MD, PhD, Department of Obstetrics & Gynecology, The Edith Wolfson Medical Center, PO Box 5, Holon 58100, Israel
    • ,
  • Letizia Schreiber, MD

      Affiliations

    • Department of Pathology, Edith Wolfson Medical Center, Holon, Israel
    • ,
  • Avi Ben-Haroush, MD

      Affiliations

    • Rabin Medical Center, Petah-Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Suzanna Wand, MD

      Affiliations

    • Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel
    • ,
  • Abraham Golan, MD

      Affiliations

    • Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel
    • ,
  • Jacob Bar, MD, MSc

      Affiliations

    • Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel

Received 12 July 2009; received in revised form 20 October 2009; accepted 12 January 2010. published online 11 March 2010.

Objective

Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders.

Study Design

Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions were classified as those consistent with maternal under-perfusion and with fetal thromboocclusive disease.

Results

Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004). Fetal villous changes were observed in 16.2% in the FGR group, compared with 3.1% in the PIH group (P = .03), and chronic villitis was 15.2% in the FGR group vs 1.6% in the PIH group (P = .004).

Conclusion

Placental lesions correspond with different clinical presentations.

Key words: fetal growth restriction, hypertension, placenta, under-perfusion, villous lesion

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 30.00 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 Cite this article as: Kovo M, Schreiber L, Ben-Haroush A, et al. Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction. Am J Obstet Gynecol 2010;202:561.e1-5.

 Authorship and contribution to the article is limited to the 6 authors indicated. There was no outside funding or technical assistance with the production of this article.

 The first 2 authors contributed equally to this article.

PII: S0002-9378(10)00023-2

doi:10.1016/j.ajog.2010.01.012

American Journal of Obstetrics & Gynecology
Volume 202, Issue 6 , Pages 561.e1-561.e5, June 2010

Article Tools

* Image Usage & Resolution