American Journal of Obstetrics & Gynecology
Volume 203, Issue 1 , Pages 21.e1-21.e6 , July 2010

Abnormal anal cytology in HIV-infected women

Presented at the 45th Annual Meeting of the Infectious Diseases Society of America, San Diego, CA, Oct. 4-7, 2007; the International Papillomavirus Conference and Clinical Workshop, Beijing, China, Nov. 3-10, 2007; the Biennial Meeting of the American Society for Colposcopy and Cervical Pathology, Orlando, FL, March 17-20, 2008; and the 56th Annual Clinical Meeting of the American College of Obstetricians and Gynecologists, New Orleans, LA, May 3-7, 2008.

  • Richa Tandon, MD

      Affiliations

    • Division of Internal Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, MA
    • ,
  • Amy S. Baranoski, MD

      Affiliations

    • Division of Internal Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, MA
    • Corresponding Author InformationReprints: Amy S. Baranoski, MD, 850 Harrison Ave., Dowling 3 North, Boston, MA 02118
    • ,
  • Faye Huang, NP

      Affiliations

    • Division of Internal Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, MA
    • ,
  • Antonio de las Morenas, MD

      Affiliations

    • Department of Pathology, Boston University Medical Center, Boston, MA
    • ,
  • Olivera Vragovic, MBA

      Affiliations

    • Division of Obstetrics and Gynecology, Boston University Medical Center, Boston, MA
    • ,
  • Meg Sullivan, MD

      Affiliations

    • Division of Internal Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, MA
    • ,
  • Elizabeth A. Stier, MD

      Affiliations

    • Division of Obstetrics and Gynecology, Boston University Medical Center, Boston, MA

Received 14 August 2009 ,Revised 21 October 2009 ,Accepted 12 January 2010.

References 

  1. Bower M, Powles T, Newsom-Davis T, et al. HIV-associated anal cancer: has highly active retroviral therapy reduced the incidence or improved the outcome?. J Acquir Immune Defic Syndr. 2004;37:1563–1565
  2. Diamond C, Taylor TH, Aboumrad T, Bringman D, Anton-Culver H. Increased incidence of squamous cell anal cancer among men with AIDS in the era of highly active antiretroviral therapy. Sex Transm Dis. 2005;32:314–320
  3. D'Souza G, Wiley DJ, Li Xiuhong, et al. Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study. J Acquir Immune Defic Syndr. 2008;48:491–499
  4. Crum-Cianflone N, Hullsiek KH, Marconi V, et al. Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. AIDS. 2009;23:41–50
  5. Frisch M, Biggar RJ, Goedert JJ. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J Natl Cancer Inst. 2000;92:1500–1510
  6. Chiao EY, Giordano TP, Palefsky JM, Tyring S, El Serag H. Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review. Clin Infect Dis. 2006;43:223–233
  7. Daling JR, Madeleine MM, Godefroy Johnson L, et al. Human papillomavirus, smoking and sexual practices in the etiology of anal cancer. Cancer. 2004;101:270–280
  8. De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S. Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis. Int J Cancer. 2008;124:1626–1636
  9. Walbloomers JMM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189:12–19
  10. Devaraj B, Cosman BC. Expectant management of anal squamous dysplasia in patients with HIV. Dis Colon Rectum. 2006;49:36–40
  11. Kitchener HC, Castle PE, Cox JT. Achievements and limitations of cervical cytology screening. Vaccine. 2006;24(suppl 3):63–70
  12. Palefsky JM, Holly EA, Hogeboom CJ, Berry JM, Jay N, Darragh TM. Anal cytology as a screening tool for anal squamous intraepithelial lesions. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;14:415–422
  13. Cranston RD, Hart JA, Hirschowitz SL, Cortina G, Moe AA. The prevalence and predictive value of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men. Int J STD AIDS. 2007;18:77–80
  14. Jay N, Berry JM, Hogeboom CJ, Holly EA, Darragh TM, Palefsky JM. Colposcopic appearance of anal squamous intraepithelial lesions: relationship to histopathology. Dis Colon Rectum. 1997;40:919–928
  15. Palefsky J. Human papillomavirus-related tumors in HIV. Curr Opin Oncol. 2006;18:463–468
  16. Moscicki AB, Durako SJ, Houser J, et al. Human papillomavirus infection and abnormal cytology of the anus in HIV-infected and uninfected adolescents. AIDS. 2003;17:311–320
  17. Palefsky JM, Holly EA, Ralston ML, Da Costa M, Greenblatt RM. Prevalence and risk factors for anal human papillomavirus infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women. J Infect Dis. 2001;183:383–391
  18. Hessol NA, Holly EA, Efird JT, et al. Anal intraepithelial neoplasia in a multisite study of HIV-infected and high-risk HIV-uninfected women. AIDS. 2009;23:59–70
  19. Durrante AJ, Williams AB, Da Costa M, Darragh TM, Khoshnood K, Palefsky JM. Incidence of anal cytological abnormalities in a cohort of human immunodeficiency virus-infected women. Cancer Epidemiol Biomarkers Prev. 2003;12:638–642
  20. Holly EA, Ralston ML, Darragh TM, Greenblatt RM, Jay N, Palefsky JM. Prevalence and risk factors for anal squamous intraepithelial lesions in women. J Natl Cancer Inst. 2001;93:843–849

 Supported by departmental funds and National Institutes of Health Grant 5 T32 AI52074-05.

 Cite this article as: Tandon R, Baranoski AS, Huang F, et al. Abnormal anal cytology in HIV-infected women. Am J Obstet Gynecol 2010;203:21.e1-6.

PII: S0002-9378(10)00021-9

doi: 10.1016/j.ajog.2010.01.010

American Journal of Obstetrics & Gynecology
Volume 203, Issue 1 , Pages 21.e1-21.e6 , July 2010

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