American Journal of Obstetrics & Gynecology
Volume 202, Issue 2 , Pages 147.e1-147.e8 , February 2010

Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the Periodontal Infections and Prematurity Study (PIPS)

Presented at the 29th Annual Meeting of the Society for Maternal-Fetal Medicine, San Diego, CA, Jan. 26-31, 2009.

  • George A. Macones, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO
    • Corresponding Author InformationReprints: George A. Macones, MD, Professor and Chair, Department of Obstetrics and Gynecology, Washington University in St. Louis, School of Medicine, Campus Box 8064, 4911 Barnes-Jewish Hospital Plaza, St. Louis, MO 63110-1094
    • ,
  • Samuel Parry, MD

      Affiliations

    • Department of Obstetrics and Gynecology, School of Medicine, University of Pennsylvania, Philadelphia, PA
    • ,
  • Deborah B. Nelson, PhD

      Affiliations

    • Departments of Public Health and Obstetrics and Gynecology, Temple University, Philadelphia, PA
    • ,
  • Jerome F. Strauss, MD, PhD

      Affiliations

    • Virginia Commonwealth University, Richmond, VA
    • ,
  • Jack Ludmir, MD

      Affiliations

    • Department of Obstetrics and Gynecology, School of Medicine, University of Pennsylvania, Philadelphia, PA
    • Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia, PA
    • ,
  • Arnold W. Cohen, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Albert Einstein Medical Center, Philadelphia, PA
    • ,
  • David M. Stamilio, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, MO
    • ,
  • Dina Appleby, MS

      Affiliations

    • Department of Biostatistics and Epidemiology, School of Medicine, University of Pennsylvania, Philadelphia, PA
    • ,
  • Bonnie Clothier, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, School of Medicine, University of Pennsylvania, Philadelphia, PA
    • ,
  • Mary D. Sammel, ScD

      Affiliations

    • Department of Biostatistics and Epidemiology, School of Medicine, University of Pennsylvania, Philadelphia, PA
    • ,
  • Marjorie Jeffcoat, DMD

      Affiliations

    • School of Dentistry, University of Pennsylvania, Philadelphia, PA

Received 7 April 2009 ,Revised 10 August 2009 ,Accepted 29 October 2009.

References 

  1. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371:75–84
  2. Parry S, Strauss J. Premature rupture of the fetal membranes. N Engl J Med. 1998;338:663–670
  3. Jeffcoat MK, Geurs NC, Reddy MS, Goldenberg RL, Hauth JC. Current evidence regarding periodontal disease as a risk factor in preterm birth. Ann Periodontol. 2001;6:183–188
  4. Goepfert AR, Jeffcoat MK, Andrews WW, et al. Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol. 2004;104:777–783
  5. Jeffcoat MK, Geurs NC, Reddy MS, Cliver SP, Goldenberg RL, Hauth JC. Periodontal infection and preterm birth: results of a prospective study. J Am Dent Assoc. 2001;132:875–880
  6. Offenbacher S, Katz V, Fertik G, et al. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol. 1996;67(suppl):1103–1113
  7. Offenbacher SBK, Murtha AP, Jared HL, et al. Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol. 2006;107:29–36
  8. Kim K, Demets D. Sample size determination for group sequential clinical trials with immediate response. Stat Med. 1992;11:1391–1399
  9. Jeffcoat M, Geurs N, Reddy M, Cliver S, Goldenerg R, Hauth J. Peridontal infection and preterm birth: results of a prospective study. J Am Dent Assoc. 2001;132:875–880
  10. Vergnes JN, Sixou M. Preterm low birth weight and maternal periodontal status: a meta-analysis. Am J Obstet Gynecol. 2007;196:135.e1–135.e7
  11. Michalowicz BS, Hodges JS, DiAngelis AJ, et al. Treatment of periodontal disease and the risk of preterm birth. N Engl J Med. 2006;355:1885–1894
  12. Lopez N, Smith P, Gutierrez J. Periodontal therapy may reduce the risk of preterm low birthweight in women with periodontal disease: a randomized controlled trial. J Peridontol. 2002;73:911–924

 Supported in part by a Grant from the Pennsylvania Department of Health, by Grant number UL1-RR-024134 from the National Center for Research Resources, and by Grant P60 MD002256 from the National Center on Minority and Health Disparities (J.F.S.).

 The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.

 Cite this article as: Macones GA, Parry S, Nelson DB, et al. Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the Periodontal Infections and Prematurity Study (PIPS). Am J Obstet Gynecol 2010;202:147.e1-8.

PII: S0002-9378(09)02118-8

doi: 10.1016/j.ajog.2009.10.892

American Journal of Obstetrics & Gynecology
Volume 202, Issue 2 , Pages 147.e1-147.e8 , February 2010

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