Pelvic pain and surgeries in women before interstitial cystitis/painful bladder syndrome
Received 28 May 2009; received in revised form 13 August 2009; accepted 19 October 2009. published online 21 December 2009.
Objective
The objective of the study was to compare subjects with interstitial cystitis/painful bladder syndrome (IC/PBS) with controls on prior surgeries.
Study Design
IC/PBS subjects were compared with matched controls on surgeries and possible surgical indications prior to their index dates.
Results
Adjusted for demographic variables, logistic regression showed subjects exceeded controls in surgeries longer than 12 months and less than 1 month before the index date. However, addition of possible surgical indications showed chronic pelvic pain (CPP) to have a strong association with IC/PBS, whereas associations with surgeries were reduced to nonsignificance.
Conclusion
Although women with IC/PBS were more likely to have experienced prior surgeries than controls, the apparent indications for surgeries, not the surgeries themselves, were stronger risk factors for IC/PBS. In particular, a prior history of CPP had a strong association with IC/PBS. Several features of study design, including extensive medical record review, suggest that prior CPP was not undiagnosed IC/PBS. Further investigation of CPP may yield insight into the pathogenesis of IC/PBS.
aDepartment of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, MD
bDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD
cDepartment of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, MD
dDepartment of Anesthesiology and Medicine, University of Michigan Medical School, Ann Arbor, MI
eDepartment of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, NY
fDepartment of Anesthesiology, University of Alabama School of Medicine, Birmingham, AL
Reprints not available from the authors.
This study was supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Grant R01 DK 064880.
Cite this article as: Langenberg PW, Wallach EE, Clauw DJ, et al. Pelvic pain and surgeries in women before interstitial cystitis/painful bladder syndrome. Am J Obstet Gynecol 2010;202:286.e1-6.
ABSTRACT