American Journal of Obstetrics & Gynecology
Volume 202, Issue 2 , Pages 139.e1-139.e6 , February 2010

An alternative monitoring protocol for single-dose methotrexate therapy in ectopic pregnancy

  • Andrea Ries Thurman, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Eastern Virginia Medical School, CONRAD Clinical Research Center, Norfolk, VA
    • Corresponding Author InformationReprints: Andrea Ries Thurman, MD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, CONRAD Clinical Research Center, 601 Colley Ave., Norfolk, VA 23507
    • ,
  • Melani Cornelius, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX
    • ,
  • Jeffrey E. Korte, PhD

      Affiliations

    • Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC
    • ,
  • Donald L. Fylstra, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC

Received 10 May 2009 ,Revised 4 July 2009 ,Accepted 24 September 2009.

References 

  1. Stovall TG, Ling FW, Gray LA. Single-dose methotrexate for treatment of ectopic pregnancy. Obstet Gynecol. 1991;77:754–757
  2. Stovall TG, Ling FW. Single dose methotrexate: an expanded clinical trial. Am J Obstet Gynecol. 1993;168:1759–1765
  3. Fylstra DL. Medical management of ectopic pregnancy: ACOG practice bulletin no. 94. Washington, DC: American College of Obstetricians and Gynecologists; 2008;
  4. Barnhart KT, Gosman G, Ashby R, Sammel M. The medical management of ectopic pregnancy: a meta-analysis comparing ‘single dose' and ‘multidose' regimens. Obstet Gynecol. 2003;101:778–784
  5. Natale A, Candiani M, Barbieri M, Calia C, Odorizzi MP, Busacca M. Pre- and post-treatment patterns of human chorionic gonadotropin for early detection of persistence after a single dose of methotrexate for ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol. 2004;117:87–92
  6. Natale A, Busacca M, Candiani M, et al. Human chorionic gonadotropin patterns after a single dose of methotrexate for ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol. 2002;100:227–230
  7. Lipscomb GH, Stovall TG, Ling FW. Nonsurgical treatment of ectopic pregnancy. N Engl J Med. 2000;343:1325–1329
  8. Bernaschek G, Rudelstorfer R, Csaicsich P. Vaginal sonography versus serum human chorionic gonadotropin in early detection of pregnancy. Am J Obstet Gynecol. 1988;158:608–612
  9. Kadar N, DeVore G, Romero R. Discriminatory hCG zone: its use in the sonographic evaluation for ectopic pregnancy. Obstet Gynecol. 1981;58:156–161
  10. American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: the practice committee of the American Society for Reproductive Medicine. Fertil Steril. 2006;86:S96–S102
  11. Gabbur N, Sherer DM, Hellmann M. Do serum beta-human chorionic gonadotropin levels on day 4 following methotrexate treatment of patients with ectopic pregnancy predict successful single-dose therapy?. Am J Perinatol. 2006;23:193–196
  12. Potter MB, Lepine LA, Jamieson DJ. Predictors of success with methotrexate treatment of tubal ectopic pregnancy at Grady Memorial Hospital. Am J Obstet Gynecol. 2003;188:1192–1194
  13. Lipscomb GH, McCord ML, Stovall TG, Huff G, Portera SG, Ling FW. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med. 1999;341:1974–1978
  14. Tulandi T. Methotrexate treatment of tubal and interstitial ectopic pregnancy. http://utdol.com/online/content/topic.do?Key=gen_gyne/11036&selectedTitle=3∼124&source=search_resultAccessed March 8, 2009
  15. Alshimmiri MM, Al-Saleh EA, Al-Harmi JA, Al-Salili MB, Al Advani A, Ibrahim ME. Treatment of ectopic pregnancy with a single intramuscular dose of methotrexate. Arch Gynecol Obstet. 2003;268:181–183

 Cite this article as: Thurman AR, Cornelius M, Korte JE, et al. An alternative monitoring protocol for single-dose methotrexate therapy in ectopic pregnancy. Am J Obstet Gynecol 2010;202:139.e1-6.

PII: S0002-9378(09)01103-X

doi: 10.1016/j.ajog.2009.09.031

American Journal of Obstetrics & Gynecology
Volume 202, Issue 2 , Pages 139.e1-139.e6 , February 2010

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