Hereditary thrombophilia and recurrence of ischemic placental disease
Received 21 January 2009; received in revised form 5 June 2009; accepted 17 August 2009. published online 27 September 2009.
Objective
We sought to evaluate whether testing for hereditary thrombophilia alone or in combination with second-trimester uterine artery Doppler (UAD) is useful in predicting recurrent complications in patients with previous preeclampsia, placental abruption, or stillbirth.
Study Design
Between 2001 and 2005, 110 consecutive women were included in the study and received 100 mg of aspirin daily. Adjustment was made for several maternal confounding factors using a logistic regression model.
Results
After multivariable logistic regression analyses, only abnormal UAD assessment was significantly associated with recurrent complications (odds ratio, 11.2; 95% confidence interval, 3.8–32.6) Combining the results of UAD and the presence of laboratory markers of thrombophilia failed to improve the accuracy of UAD to predict recurrent complications.
Conclusion
Hereditary thrombophilia testing is not useful in predicting recurrent complications in subsequent pregnancy.
aDepartment of Obstetrics and Gynecology, Rouen University Hospital, Rouen, France
bDepartment of Haematology and Coagulation Disorders, Rouen University Hospital, Rouen, France
cDepartment of Obstetrics and Gynecology, Maternité Mathilde, Rouen, France
dDepartment of Obstetrics and Gynecology, Maternité Elbeuf, Elbeuf, France
Reprints: Eric Verspyck, MD, Clinique Gynécologique et Obstétricale, Hôpital Charles Nicolle-CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France
Cite this article as: Verspyck E, Borg J-Y, Roman H, et al. Hereditary thrombophilia and recurrence of ischemic placental disease. Am J Obstet Gynecol 2010;202:54.e1-5.
ABSTRACT
Hereditary thrombophilia and recurrence of ischemic placental disease