American Journal of Obstetrics & Gynecology
Volume 202, Issue 1 , Pages 54.e1-54.e5, January 2010

Hereditary thrombophilia and recurrence of ischemic placental disease

  • Eric Verspyck, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Rouen University Hospital, Rouen, France
    • Corresponding Author InformationReprints: Eric Verspyck, MD, Clinique Gynécologique et Obstétricale, Hôpital Charles Nicolle-CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France
    • ,
  • Jeanne-Yvonne Borg, MD

      Affiliations

    • Department of Haematology and Coagulation Disorders, Rouen University Hospital, Rouen, France
    • ,
  • Horace Roman, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Rouen University Hospital, Rouen, France
    • ,
  • Bernard Thobois, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Maternité Mathilde, Rouen, France
    • ,
  • Patrick Pia, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Maternité Elbeuf, Elbeuf, France
    • ,
  • Loïc Marpeau, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Rouen University Hospital, Rouen, France

Received 21 January 2009; received in revised form 5 June 2009; accepted 17 August 2009. published online 27 September 2009.

Objective

We sought to evaluate whether testing for hereditary thrombophilia alone or in combination with second-trimester uterine artery Doppler (UAD) is useful in predicting recurrent complications in patients with previous preeclampsia, placental abruption, or stillbirth.

Study Design

Between 2001 and 2005, 110 consecutive women were included in the study and received 100 mg of aspirin daily. Adjustment was made for several maternal confounding factors using a logistic regression model.

Results

After multivariable logistic regression analyses, only abnormal UAD assessment was significantly associated with recurrent complications (odds ratio, 11.2; 95% confidence interval, 3.8–32.6) Combining the results of UAD and the presence of laboratory markers of thrombophilia failed to improve the accuracy of UAD to predict recurrent complications.

Conclusion

Hereditary thrombophilia testing is not useful in predicting recurrent complications in subsequent pregnancy.

Key words: adverse pregnancy outcome, screening, subsequent pregnancy, thrombophilia, uterine artery Doppler

 

 Cite this article as: Verspyck E, Borg J-Y, Roman H, et al. Hereditary thrombophilia and recurrence of ischemic placental disease. Am J Obstet Gynecol 2010;202:54.e1-5.

PII: S0002-9378(09)00944-2

doi:10.1016/j.ajog.2009.08.019

American Journal of Obstetrics & Gynecology
Volume 202, Issue 1 , Pages 54.e1-54.e5, January 2010