American Journal of Obstetrics & Gynecology
Volume 202, Issue 1 , Pages 51.e1-51.e10, January 2010

Association between prepregnancy body mass index and congenital heart defects

Presented at the 13th Annual Maternal and Child Health Epidemiology Conference, Atlanta, GA, Dec. 10-12, 2007.

  • Suzanne M. Gilboa, PhD

      Affiliations

    • National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Adolfo Correa, MD, PhD

      Affiliations

    • National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Lorenzo D. Botto, MD

      Affiliations

    • Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT
    • ,
  • Sonja A. Rasmussen, MD, MS

      Affiliations

    • National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • D. Kim Waller, PhD

      Affiliations

    • School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX
    • ,
  • Charlotte A. Hobbs, MD, PhD

      Affiliations

    • Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR
    • ,
  • Mario A. Cleves, PhD

      Affiliations

    • Department of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR
    • ,
  • Tiffany J. Riehle-Colarusso, MD, MSE

      Affiliations

    • National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • National Birth Defects Prevention Study

Received 21 January 2009; received in revised form 9 July 2009; accepted 6 August 2009. published online 05 October 2009.

Objective

The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs).

Study Design

These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004).

Results

Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect).

Conclusion

These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.

Key words: body mass index, congenital heart defects, gestational diabetes, obesity

 

 This work was supported in part through cooperative agreements under Program Announcement #02081 from the Centers for Disease Control and Prevention to the centers participating in the National Birth Defects Prevention Study.

 Reprints not available from the authors.

 The views expressed herein are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

 Cite this article as: Gilboa SM, Correa A, Botto LD, et al. Association between prepregnancy body mass index and congenital heart defects. Am J Obstet Gynecol 2010;202:51.e1-10.

PII: S0002-9378(09)00903-X

doi:10.1016/j.ajog.2009.08.005

American Journal of Obstetrics & Gynecology
Volume 202, Issue 1 , Pages 51.e1-51.e10, January 2010