Association between prepregnancy body mass index and congenital heart defects
Presented at the 13th Annual Maternal and Child Health Epidemiology Conference, Atlanta, GA, Dec. 10-12, 2007.
Received 21 January 2009; received in revised form 9 July 2009; accepted 6 August 2009. published online 05 October 2009.
Objective
The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs).
Study Design
These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004).
Results
Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect).
Conclusion
These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.
aNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
bDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT
cSchool of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX
dDepartment of Pediatrics, Birth Defects Research Section, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR
This work was supported in part through cooperative agreements under Program Announcement #02081 from the Centers for Disease Control and Prevention to the centers participating in the National Birth Defects Prevention Study.
Reprints not available from the authors.
The views expressed herein are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Cite this article as: Gilboa SM, Correa A, Botto LD, et al. Association between prepregnancy body mass index and congenital heart defects. Am J Obstet Gynecol 2010;202:51.e1-10.
ABSTRACT
Association between prepregnancy body mass index and congenital heart defects