Volume 202, Issue 1 , Pages 51.e1-51.e10, January 2010
Association between prepregnancy body mass index and congenital heart defects
Objective
The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs).
Study Design
These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004).
Results
Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect).
Conclusion
These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.
Key words: body mass index, congenital heart defects, gestational diabetes, obesity
This work was supported in part through cooperative agreements under Program Announcement #02081 from the Centers for Disease Control and Prevention to the centers participating in the National Birth Defects Prevention Study.
Reprints not available from the authors.
The views expressed herein are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Cite this article as: Gilboa SM, Correa A, Botto LD, et al. Association between prepregnancy body mass index and congenital heart defects. Am J Obstet Gynecol 2010;202:51.e1-10.
PII: S0002-9378(09)00903-X
doi:10.1016/j.ajog.2009.08.005
Published by Elsevier Inc.
Volume 202, Issue 1 , Pages 51.e1-51.e10, January 2010

