Tea consumption and risk of endometrial cancer: a metaanalysis
Received 26 February 2009; received in revised form 12 May 2009; accepted 14 July 2009. published online 23 September 2009.
Objective
The objective of the study was to assess the association between tea consumption and endometrial cancer.
Study Design
Studies were identified by searching PubMed and EMBASE databases and screening the references of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated.
Results
The combined RR for ever drinkers vs non/lowest drinkers was 0.85 (95% CI, 0.77–0.94). Compared with non/lowest drinkers, the summary RR was 0.88 (95% CI, 0.78–0.98) for low to moderate drinkers and 0.75 (95% CI, 0.64–0.88) for high drinkers. An increase in tea intake of 2 cups/day was associated with a 25% decreased risk of endometrial cancer. In subgroup analyses, tea consumption was significantly associated with reduced endometrial cancer risk in Asian studies and studies using interviewing techniques. Furthermore, the protective effect of green tea on endometrial cancer seemed more evident than that of black tea.
Conclusion
Findings from this metaanalysis suggest that tea consumption may reduce the risk of endometrial cancer. Because of the limited number of studies, further prospective studies are needed to explore the protective effect of tea on endometrial cancer.
National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, Pudong, Shanghai, China
Reprints: Jing Ma, PhD, or Na-Ping Tang, MD, National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, 199 Guoshoujing Rd., Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, China
Cite this article as: Tang N-P, Li H, Qiu Y-L, et al. Tea consumption and risk of endometrial cancer: a metaanalysis. Am J Obstet Gynecol 2009;201:605.e1-8.
ABSTRACT
Tea consumption and risk of endometrial cancer: a metaanalysis