American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 603.e1-603.e7, December 2009

Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting

Presented at a meeting of gynecologic oncologists within the Norwegian Forum for Oncology, Bergen, Norway, Nov. 21, 2008.

  • Elisabeth Wik, MD

      Affiliations

    • Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    • Corresponding Author InformationReprints: Elisabeth Wik, MD, Institute of Clinical Medicine, Section for Gynecology and Obstetrics, University of Bergen, Haukeland University Hospital, 5021 Bergen, Norway
    • ,
  • Jone Trovik, MD

      Affiliations

    • Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    • Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Ole E. Iversen, MD, PhD

      Affiliations

    • Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    • Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Ingeborg B. Engelsen, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Ingunn M. Stefansson, MD, PhD

      Affiliations

    • Section of Pathology, The Gade Institute, University of Bergen, Bergen, Norway
    • Department of Pathology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Liv C. Vestrheim, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Hans K. Haugland, MD, PhD

      Affiliations

    • Department of Pathology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Lars A. Akslen, MD, PhD

      Affiliations

    • Section of Pathology, The Gade Institute, University of Bergen, Bergen, Norway
    • Department of Pathology, Haukeland University Hospital, Bergen, Norway
    • ,
  • Helga B. Salvesen, MD, PhD

      Affiliations

    • Institute of Clinical Medicine, University of Bergen, Bergen, Norway
    • Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway

Received 26 February 2009; received in revised form 20 May 2009; accepted 14 July 2009. published online 05 October 2009.

Objective

The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series.

Study Design

We studied a population-based series of 363 endometrial carcinomas prospectively collected, with long and complete follow-up. The prognostic value of DNA ploidy was investigated in a routine diagnostic series (n = 262) and compared with the results from a previous research series (n = 101).

Results

The proportion of DNA aneuploid tumors was 21% in the research series and 25% in the routine diagnostic series (P = NS). In both series, DNA aneuploidy was significantly correlated to higher age at diagnosis, nonendometrioid subtype, and high histologic grade. Patients with DNA aneuploid tumors had significantly poorer survival, adjusted for established clinicopathologic prognostic factors.

Conclusion

DNA ploidy estimation in endometrial carcinoma adds independent prognostic information in a routine diagnostic setting.

Key words: deoxyribonucleic acid ploidy, endometrial carcinoma, prognostic marker, survival, validation study

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 This study was supported in part by Helse Vest and a legacy of Harald Andersen to the Norwegian Cancer Society.

 Cite this article as: Wik E, Trovik J, Iversen OE, et al. Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting. Am J Obstet Gynecol 2009;201:603.e1-7.

PII: S0002-9378(09)00816-3

doi:10.1016/j.ajog.2009.07.029

American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 603.e1-603.e7, December 2009

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