American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 608.e1-608.e8 , December 2009

Bone marrow–derived cells from male donors can compose endometrial glands in female transplant recipients

  • Tomomi Ikoma, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
  • ,
  • Satoru Kyo, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    • Corresponding Author InformationReprints: Satoru Kyo, Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
  • ,
  • Yoshiko Maida, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
  • ,
  • Satoru Ozaki, PhD

      Affiliations

    • Section of Pathology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
  • ,
  • Masahiro Takakura, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
  • ,
  • Shinji Nakao, MD, PhD

      Affiliations

    • Department of Hematology, Oncology, and Respiratory Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
  • ,
  • Masaki Inoue, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan

Received 18 March 2009 ,Revised 12 May 2009 ,Accepted 14 July 2009.

References 

  1. McLennan CE, Rydell AH. Extent of endometrial shedding during normal menstruation. Obstet Gynecol. 1965;26:605–621
  2. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143–147
  3. Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology. 2000;31:235–240
  4. Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science. 1999;284:1168–1170
  5. Alison MR, Poulsom R, Jeffery R, et al. Hepatocytes from non-hepatic adult stem cells. Nature. 2000;406:257
  6. Ferrari G, Cusella-De Angelis G, Coletta M, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science. 1998;279:1528–1530
  7. Gussoni E, Soneoka Y, Strickland CD, et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature. 1999;401:390–394
  8. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA. 1999;96:10711–10716
  9. Li Y, Chen J, Wang L, Lu M, Chopp M. Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology. 2001;56:1666–1672
  10. Fuchs E, Segre JA. Stem cells: a new lease on life. Cell. 2000;100:143–155
  11. Theise ND, Nimmakayalu M, Gardner R, et al. Liver from bone marrow in humans. Hepatology. 2000;32:11–16
  12. Korbling M, Katz RL, Khanna A, et al. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med. 2002;346:738–746
  13. Mezey E, Key S, Vogelsang G, Szalayova I, Lange GD, Crain B. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci USA. 2003;100:1364–1369
  14. Quaini F, Urbanek K, Beltrami AP, et al. Chimerism of the transplanted heart. N Engl J Med. 2002;346:5–15
  15. Taylor HS. Endometrial cells derived from donor stem cells in bone marrow transplant recipients. JAMA. 2004;292:81–85
  16. Herzog EL, Van Arnam J, Hu B, et al. Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation. FASEB J. 2007;21:2592–2601
  17. Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007;25:2082–2086
  18. Tanaka M, Kyo S, Kanaya T, et al. Evidence of the monoclonal composition of human endometrial epithelial glands and mosaic pattern of clonal distribution in luminal epithelium. Am J Pathol. 2003;3:295–301
  19. Mints M, Jansson M, Sadeghi B, et al. Endometrial endothelial cells are derived from donor stem cells in a bone marrow transplant recipient. Hum Reprod. 2008;23:139–143
  20. Meirow D. Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol. 2000;169:123–131
  21. Gulati SC, Van Poznak C. Pregnancy after bone marrow transplantation. Clin Oncol. 1998;5:1978–1985
  22. Stevens AM, McDonnel WM, Nelson JL. Male cells in female recipients of hematopoietic-cell transplants. N Engl J Med. 2002;347:218–220

 This study was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science and the Megumi Medical foundation of Kanazawa University.

 Cite this article as: Ikoma T, Kyo S, Maida Y, et al. Bone marrow–derived cells from male donors can compose endometrial glands in female transplant recipients. Am J Obstet Gynecol 2009;201:608.e1-8.

PII: S0002-9378(09)00813-8

doi: 10.1016/j.ajog.2009.07.026

American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 608.e1-608.e8 , December 2009