American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 576.e1-576.e6, December 2009

Does frank diabetes in first-degree relatives of a pregnant woman affect the likelihood of her developing gestational diabetes mellitus or nongestational diabetes?

  • Catherine Kim, MD, MPH

      Affiliations

    • Departments of Medicine and Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI
    • ,
  • Tiebin Liu, MSPH

      Affiliations

    • National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Rodolfo Valdez, PhD, MSc

      Affiliations

    • National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Gloria L. Beckles, MD, MSc

      Affiliations

    • Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA

Received 16 April 2009; received in revised form 9 June 2009; accepted 29 June 2009. published online 19 August 2009.

Objective

We sought to examine the associations between patterns of family histories of diabetes and a history of gestational diabetes mellitus (hGDM).

Study Design

Parous women participating in the National Health and Nutrition Examination Survey III (n = 4566) were classified as having hGDM only, diagnosed diabetes, or neither. Family history of diabetes was categorized as: maternal only, paternal only, biparental, and sibling only. The covariate-adjusted prevalence and odds of having hGDM were estimated.

Results

Compared to women without a family history of diabetes, women with a maternal (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.2–7.3), paternal (OR, 3.3; 95% CI, 1.1–10.2), or sibling (OR, 7.1; 95% CI, 1.6–30.9) history of diabetes had greater odds of hGDM, after adjustment for age and race/ethnicity.

Conclusion

Women with a sibling history of diabetes were more likely to have hGDM than women with other family history patterns.

Key words: family history, gestational diabetes, sibling

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 Reprints not available from the authors.

 Supported by K23DK071552 from the National Institute of Diabetes and Digestive and Kidney Diseases (Dr Kim) and by the Centers for Disease Control and Prevention (Drs Valdez and Beckles, and Mr Liu).

 The findings and conclusions in this article are those of the authors and do not necessarily represent the official positions of the funding agency or of the Centers for Disease Control and Prevention.

 Cite this article as: Kim C, Liu T, Valdez R, et al. Does frank diabetes in first-degree relatives of a pregnant woman affect the likelihood of her developing gestational diabetes mellitus or nongestational diabetes? Am J Obstet Gynecol 2009;201:576.e1-6.

PII: S0002-9378(09)00764-9

doi:10.1016/j.ajog.2009.06.069

American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 576.e1-576.e6, December 2009

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