American Journal of Obstetrics & Gynecology
Volume 201, Issue 4 , Pages 402.e1-402.e5 , October 2009

Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes

Presented as a poster at the 29th Annual Meeting of the Society for Maternal-Fetal Medicine, San Diego, CA, Jan. 28-31, 2009.

  • S. Katherine Laughon, MD, MS

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Corresponding Author InformationReprints: S. Katherine Laughon, MD, MS, NICHD/National Institutes of Health, Division of Epidemiology, Statistics and Prevention Research, Building 6100, Room 7B03, Bethesda, MD 20892
    • ,
  • Janet Catov, PhD

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Traci Provins

      Affiliations

    • Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • James M. Roberts, MD

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Robin E. Gandley, PhD

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Department of Environmental and Occupational Health, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA

Received 26 February 2009 ,Revised 1 June 2009 ,Accepted 30 June 2009.

References 

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  2. Nakagawa T, Tuttle KR, Short RA, Johnson RJ. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol. 2005;1:80–86
  3. Masuo K, Kawaguchi H, Mikami H, Ogihara T, Tuck ML. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension. 2003;42:474–480
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 Funding was provided by Grant NIH P01 HD030367 for the Pregnancy Exposures and Preeclampsia Prevention Study and by the University of Pittsburgh Clinical and Translational Science Award UL1 RR024153 for Magee-Womens Hospital Clinical and Translational Research Center.

 Cite this article as: Laughon SK, Catov J, Provins T, et al. Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes. Am J Obstet Gynecol 2009;201:402.e1-5.

PII: S0002-9378(09)00760-1

doi: 10.1016/j.ajog.2009.06.065

American Journal of Obstetrics & Gynecology
Volume 201, Issue 4 , Pages 402.e1-402.e5 , October 2009

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