American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 582.e1-582.e6 , December 2009

Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women

Presented as a poster at the 55th Annual Scientific Meeting of the Society for Gynecologic Investigation, San Diego, CA, March 26-29, 2008.

  • S. Katherine Laughon, MD, MS

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Corresponding Author InformationReprints: S. Katherine Laughon, MD, MS, Magee-Women's Hospital, University of Pittsburgh, 300 Halket St., Room 2229, Pittsburgh, PA 15213
  • ,
  • Janet Catov, PhD, MS

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Magee-Women's Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • ,
  • James M. Roberts, MD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Magee-Women's Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA

Received 14 November 2008 ,Revised 22 May 2009 ,Accepted 16 June 2009.

References 

  1. NCHS Health-E Stats. Prevalence of overweight, obesity and extreme obesity among adults: United States, trends 1976–80 through 2005–2006. http://www.cdc.gov/nchs/products/pubs/pubd/hestats/overweight/overweight_adult.pdfDec 2008;Accessed May 22, 2009
  2. Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol. 2008;28:629–636
  3. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third national health and nutrition examination survey. JAMA. 2002;287:356–359
  4. Cedergren MI. Maternal morbid obesity and the risk of adverse pregnancy outcome. Obstet Gynecol. 2004;103:219–224
  5. Cnattingius S, Bergstrom R, Lipworth L, Kramer MS. Prepregnancy weight and the risk of adverse pregnancy outcomes. N Engl J Med. 1998;338:147–152
  6. Kristensen J, Vestergaard M, Wisborg K, Kesmodel U, Secher NJ. Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG. 2005;112:403–408
  7. Choi HK, Ford ES. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med. 2007;120:442–447
  8. Redman CW, Beilin LJ, Bonnar J, Wilkinson RH. Plasma-urate measurements in predicting fetal death in hypertensive pregnancy. Lancet. 1976;1:1370–1373
  9. Roberts JM, Bodnar LM, Lain KY, et al. Uric acid is as important as proteinuria in identifying fetal risk in women with gestational hypertension. Hypertension. 2005;46:1263–1269
  10. Hadden DR. Prediabetes and the big baby. Diabet Med. 2008;25:1–10
  11. Wolf M, Sandler L, Munoz K, Hsu K, Ecker JL, Thadhani R. First trimester insulin resistance and subsequent preeclampsia: a prospective study. J Clin Endocrinol Metab. 2002;87:1563–1568
  12. Wolf M, Sandler L, Jimenez-Kimble R, Shah A, Ecker JL, Thadhani R. Insulin resistance but not inflammation is associated with gestational hypertension. Hypertension. 2002;40:886–891
  13. Weisz B, Cohen O, Homko CJ, Schiff E, Sivan E. Elevated serum uric acid levels in gestational hypertension are correlated with insulin resistance. Am J Perinatol. 2005;22:139–144
  14. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  15. Powers RW, Bodnar LM, Ness RB, et al. Uric acid concentrations in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery. Am J Obstet Gynecol. 2006;194:160
  16. Modan M, Halkin H, Karasik A, Lusky A. Elevated serum uric acid—a facet of hyperinsulinemia. Diabetologia. 1987;30:713–718
  17. Coutinho Tde A, Turner ST, Peyser PA, Bielak LF, Sheedy PF, Kullo IJ. Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis. Am J Hypertens. 2007;20:83–89
  18. Quinones Galvan A, Natali A, Baldi S, et al. Effect of insulin on uric acid excretion in humans. Am J Physiol. 1995;268:E1–E5
  19. Cappuccio FP, Strazzullo P, Farinaro E, Trevisan M. Uric acid metabolism and tubular sodium handling: results from a population-based study. JAMA. 1993;270:354–359
  20. Facchini F, Chen YD, Hollenbeck CB, Reaven GM. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA. 1991;266:3008–3011
  21. Dehghan A, van Hoek M, Sijbrands EJ, Hofman A, Witteman JC. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care. 2008;31:361–362
  22. Johnson RJ, Segal MS, Srinivas T, et al. Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?. J Am Soc Nephrol. 2005;16:1909–1919
  23. Barden A, Singh R, Walters BN, Ritchie J, Roberman B, Beilin LJ. Factors predisposing to pre-eclampsia in women with gestational diabetes. J Hypertens. 2004;22:2371–2378
  24. Kanellis J, Kang DH. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol. 2005;25:39–42
  25. Bainbridge SA, Roberts JM. Uric acid as a pathogenic factor in preeclampsia. Placenta. 2008;29(suppl A):S67–S72
  26. Sanchez-Lozada LG, Tapia E, Soto V, et al. Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricemia. Nephrol Dial Transplant. 2008;23:1179–1185
  27. Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?. Atherosclerosis. 2000;148:131–139
  28. Parks DA, Williams TK, Beckman JS. Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a reevaluation. Am J Physiol. 1988;254:G768–G774
  29. Abuja PM. Ascorbate prevents prooxidant effects of urate in oxidation of human low density lipoprotein. FEBS Lett. 1999;446:305–308
  30. Bainbridge SA, von Versen-Hoynck F, Roberts JM. Uric acid inhibits placental system A amino acid uptake. Placenta. 2009;30:195–200

 Funding for the Pregnancy Exposures and Preeclampsia Prevention Study, Magee-Women's Hospital: National Institutes of Health Grant P01 HD030367. Funding for the Clinical and Translational Research Center: Clinical and Translational Science Award, UL1 RR024153, University of Pittsburgh School of Medicine.

 Cite this article as: Laughon SK, Catov J, Roberts JM. Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women. Am J Obstet Gynecol 2009;201:582.e1-6.

PII: S0002-9378(09)00687-5

doi: 10.1016/j.ajog.2009.06.043

American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 582.e1-582.e6 , December 2009