American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 582.e1-582.e6, December 2009

Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women

Presented as a poster at the 55th Annual Scientific Meeting of the Society for Gynecologic Investigation, San Diego, CA, March 26-29, 2008.

  • S. Katherine Laughon, MD, MS

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Corresponding Author InformationReprints: S. Katherine Laughon, MD, MS, Magee-Women's Hospital, University of Pittsburgh, 300 Halket St., Room 2229, Pittsburgh, PA 15213
    • ,
  • Janet Catov, PhD, MS

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Magee-Women's Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • ,
  • James M. Roberts, MD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Department of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
    • Magee-Women's Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA

Received 14 November 2008; received in revised form 22 May 2009; accepted 16 June 2009. published online 03 September 2009.

Objective

We sought to investigate whether uric acid concentrations are increased in pregnant women with insulin resistance and to correlate both with fetal growth.

Study Design

Uric acid, glucose, and insulin were measured in plasma at 20.4 (±2.0) weeks' gestation in 263 women. The association between uric acid and insulin resistance, as estimated using the homeostasis model assessment (HOMA), was analyzed and related to birthweights.

Results

In 212 (80.6%) women who remained normotensive throughout pregnancy, HOMA increased 1.23 U per 1-mg/dL increase in uric acid (95% confidence interval, 1.07–1.42; P = .003). Infants born to normotensive women in the upper quartile of uric acid and lowest HOMA quartile weighed 435.6 g less than infants of women with highest uric acid and HOMA quartiles (P < .005).

Conclusion

Increasing uric acid concentrations were associated with insulin resistance in midpregnancy. Hyperuricemia was associated with lower birthweight in normotensive women, and this effect was attenuated by insulin resistance.

Key words: birthweight, hyperuricemia, insulin resistance, uric acid

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 Funding for the Pregnancy Exposures and Preeclampsia Prevention Study, Magee-Women's Hospital: National Institutes of Health Grant P01 HD030367. Funding for the Clinical and Translational Research Center: Clinical and Translational Science Award, UL1 RR024153, University of Pittsburgh School of Medicine.

 Cite this article as: Laughon SK, Catov J, Roberts JM. Uric acid concentrations are associated with insulin resistance and birthweight in normotensive pregnant women. Am J Obstet Gynecol 2009;201:582.e1-6.

PII: S0002-9378(09)00687-5

doi:10.1016/j.ajog.2009.06.043

American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 582.e1-582.e6, December 2009

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