American Journal of Obstetrics & Gynecology
Volume 201, Issue 5 , Pages 462.e1-462.e4 , November 2009

Malignancy in endometrial polyps: a 12-year experience

  • Gabriela Baiocchi, MD

      Affiliations

    • Department of Gynecology and Obstetrics, Santa Maria della Misericordia University Hospital, Perugia, Italy
    • ,
  • Natalina Manci, MD

      Affiliations

    • Department of Gynecology and Obstetrics, La Sapienza University, Policlinico Umberto I, Rome, Italy
    • ,
  • Michela Pazzaglia, MD

      Affiliations

    • Department of Gynecology and Obstetrics, Santa Maria della Misericordia University Hospital, Perugia, Italy
    • ,
  • Laura Giannone, MD

      Affiliations

    • Department of Gynecology and Obstetrics, Santa Maria della Misericordia University Hospital, Perugia, Italy
    • ,
  • Liliana Burnelli, MD

      Affiliations

    • Department of Gynecology and Obstetrics, Santa Maria della Misericordia University Hospital, Perugia, Italy
    • ,
  • Ettore Giannone, MD

      Affiliations

    • Department of Gynecology and Obstetrics, Santa Maria della Misericordia University Hospital, Perugia, Italy
    • ,
  • Daniela Fratini, MD

      Affiliations

    • Institute of Pathology, Perugia University, Perugia, Italy
    • ,
  • Gian Carlo Di Renzo, MD, PhD

      Affiliations

    • Department of Gynecology and Obstetrics, Santa Maria della Misericordia University Hospital, Perugia, Italy
    • Corresponding Author InformationReprints: Gian Carlo Di Renzo, MD, PhD, Department of Obstetrics and Gynecology and Centre for Perinatal and Reproductive Medicine, Santa Maria della Misericordia University Hospital, 06132 San Sisto-Perugia, Italy

Received 12 November 2008 ,Revised 10 April 2009 ,Accepted 28 May 2009.

References 

  1. Schlaen I, Bergeron C, Ferenczy A, Wong P, Naves A. Endometrial polyps: a study of 204 cases. Surg Pathol. 1988;1:375–382
  2. DeWaay DJ, Syrop CH, Nygaard IE, Davis WA, Van Voorhis BJ. Natural history of uterine polyps and leiomyomata. Obstet Gynecol. 2002;100:3–7
  3. De Vries L, Dijkhuizen F, Mol B, Brolmann H, Moret E, Heintz A. Comparison of transvaginal sonography, saline infusion sonography, and hysteroscopy in premenopausal women with abnormal uterine bleeding. J Clin Ultrasound. 2000;28:217–223
  4. Widrich T, Bradley L, Mitchinson A, Collins R. Comparison of saline infused sonography with office hysteroscopy for the evaluation of the endometrium. Am J Obstet Gynecol. 1996;174:1327–1334
  5. Sherman ME, Mazur MT, Kurman RJ. Benign diseases of the endometrium. In:  Kurman RJ editors. Blaunstein's pathology of the female genital tract. 3rd ed.. New York, NY: Springer; 2002;
  6. Goldstein SR, Monteagudo A, Popiolek D, Mayberry P, Timor-Tritsch I. Evaluation of endometrial polyps. Am J Obstet Gynecol. 2002;186:669–674
  7. Caspi B, Appelman Z, Goldchmit R, Ashkenazi M, Haruvy Y, Hagay Z. The bright edge of the endometrial polyp. Ultrasound Obstet Gynecol. 2000;15:327–330
  8. Clevenger-Hoeft M, Syrop CH, Stovall DW, Van Voorhis BJ. Sonohysterography in premenopausal women with and without abnormal bleeding. Obstet Gynecol. 1999;94:516–520
  9. Cohen I, Azaria R, Aviram R, et al. Postmenopausal endometrial pathologies with tamoxifen treatment: comparison between hysteroscopic and hysterectomy findings. Gynecol Obstet Invest. 1999;48:187–192
  10. Orovieto R, Bar-Hava I, Dicker D, Bar J, Ben-Rafael Z, Neri A. Endometrial polyps during menopause: characterization and significance. Acta Obstet Gynecol Scand. 1999;78:883–886
  11. Ben-Arie A, Goldchmit C, Laviv Y, et al. The malignant potential of endometrial polyps. Eur J Obstet Gynecol. 2004;115:206–210
  12. Sant'Ana de Almeida EC, Nogueira AA, Candido dos Reis FJ, Zambelli Ramalho LN, Zucoloto S. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women. Maturitas. 2004;49:229–233
  13. Cheng WF, Lin HH, Torng PL, Huang SC. Comparison of endometrial changes among symptomatic tamoxifen-treated and nontreated premenopausal and postmenopausal breast cancer patients. Gynecol Oncol. 1997;66:233–237
  14. McGurgan P, Taylor LJ, Duffy SR, O'Donovan PJ. An immunohistochemical comparison of endometrial polyps from postmenopausal women exposed and not exposed to HRT. Maturitas. 2006;53:454–461
  15. Salm R. The incidence and significance of early carcinomas in endometrial polyps. Pathology. 1972;108:47–53
  16. Anastasiadis PG, Koutlaki NG, Skaphida PG, Galazios GC, Tsikouras PN, Liberis VA. Endometrial polyps: prevalence, detection, and malignant potential in women with abnormal uterine bleeding. Eur J Gynaecol Oncol. 2000;21:180–183
  17. Wolfe SA, Mackles A. Malignant lesions arising from benign endometrial polyps. Obstet Gynecol. 1962;20:542–550
  18. Bakour SH, Khan KS, Gupta JK. The risk of premalignant and malignant pathology in endometrial polyps. Acta Obstet Gynecol Scand. 2000;79:317–320
  19. Savelli L, De Iaco P, Santini D, et al. Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps. Am J Obstet Gynecol. 2003;188:927–931
  20. In:  Kurman RJ editors. Blaustein's pathology of the female genital tract. 5th ed.. New York: Springer-Verlag; 2002;
  21. Hassa H, Tekin B, Senses T, Kaya M, Karatas A. Are the site, diameter, and number of endometrial polyps related with the symptomatology?. Am J Obstet Gynecol. 2006;194:718–721
  22. Giordano G, Gnetti L, Merisio C, Melpignano M. Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. Maturitas. 2007;20:190–197
  23. Antunes A, Costa-Paiva L, Arthuso M, Costa JV, Pinto-Neto AM. Endometrial polyps in pre- and postmenopausal women: factors associated with malignancy. Maturitas. 2007;57:415–421
  24. Hileeto D, Fadare O, Martel M, Zheng W. Age dependent association of endometrial polyps with increased risk of cancer involvement. World J Surg Oncol. 2005;3:8
  25. Oguz S, Sargin A, Kelekci S, Aytan H, Tapisiz OL, Mollamahmutoglu L. The role of hormone replacement therapy in endometrial polyp formation. Maturitas. 2005;50:231–236
  26. Bergman L, Beelen ML, Gallee MP, Hollema H, Benraadt J, van Leeuwen FE. Risk and prognosis of endometrial cancer after tamoxifen for breast cancer (Comprehensive Cancer Centres' ALERT Group. Assessment of liver and endometrial cancer risk following tamoxifen). Lancet. 2000;356:881–887

 Cite this article as: Baiocchi G, Manci N, Pazzaglia M, et al. Malignancy in endometrial polyps: a 12-year experience. Am J Obstet Gynecol 2009;201:462.e1-4.

PII: S0002-9378(09)00568-7

doi: 10.1016/j.ajog.2009.05.055

American Journal of Obstetrics & Gynecology
Volume 201, Issue 5 , Pages 462.e1-462.e4 , November 2009

Article Tools