American Journal of Obstetrics & Gynecology
Volume 201, Issue 3 , Pages 260.e1-260.e3, September 2009

How valid are current cervical cancer prognostic factors that are used to recommend adjunctive radiation therapy after radical surgery?

  • William T. Creasman, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC
    • ,
  • Matthew Kohler, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC
    • ,
  • Jeffrey E. Korte, PhD

      Affiliations

    • Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC

Received 11 November 2008; accepted 9 April 2009. published online 19 June 2009.

Prognostic factors in early cervical cancer have been debated for many years and have been used as an indication for postradical hysterectomy radiation therapy. A recent Gynecologic Oncology Group protocol suggested that large lesions, deep invasion, or capillary-like space had better recurrence-free survival, but not overall survival, if postoperative radiation was given. When the published data were evaluated, the authors' conclusions were questioned. The choice of prognostic factors does not seem appropriate based on the data that were presented.

Key words: cervical cancer, prognostic factor

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 Cite this article as: Creasman WT, Kohler M, Korte JE. How valid are current cervical cancer prognostic factors that are used to recommend adjunctive radiation therapy after radical surgery? Am J Obstet Gynecol 2009;201:260.e1-3.

 Reprints not available from the authors.

 Authorship and contribution to the article is limited to the 3 authors indicated. There was no outside funding or technical assistance with the production of this article.

PII: S0002-9378(09)00406-2

doi:10.1016/j.ajog.2009.04.020

American Journal of Obstetrics & Gynecology
Volume 201, Issue 3 , Pages 260.e1-260.e3, September 2009

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