American Journal of Obstetrics & Gynecology
Volume 200, Issue 6 , Pages 678.e1-678.e6 , June 2009

Incidence of endometrial hyperplasia

Presented at the 75th Annual Meeting of the Pacific Coast Obstetrical and Gynecological Society, Victoria, BC, Canada, Oct. 15-19, 2008.

  • Susan D. Reed, MD, MPH

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
    • Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA
    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA
    • Center for Health Studies, Group Health, Seattle, WA
    • ,
  • Katherine M. Newton, PhD

      Affiliations

    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA
    • Center for Health Studies, Group Health, Seattle, WA
    • ,
  • Walter L. Clinton, PhD

      Affiliations

    • Center for Health Studies, Group Health, Seattle, WA
    • ,
  • Meira Epplein, PhD

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA
    • ,
  • Rochelle Garcia, MD

      Affiliations

    • Department of Pathology, University of Washington School of Medicine, Seattle, WA
    • ,
  • Kimberly Allison, MD

      Affiliations

    • Department of Pathology, University of Washington School of Medicine, Seattle, WA
    • ,
  • Lynda F. Voigt, PhD

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA
    • ,
  • Noel S. Weiss, DrPH, MD

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA

Received 23 August 2008 ,Revised 9 December 2008 ,Accepted 26 February 2009.

References 

  1. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia (A long-term study of “untreated” hyperplasia in 170 patients). Cancer. 1985;56:403–412
  2. Pecorelli S, Benedet JL, Creasman WT, Shepherd JH. FIGO staging of gynecologic cancer. 1994-1997 FIGO Committee on Gynecologic Oncology. International Federation of Gynecology and Obstetrics Int J Gynaecol Obstet. 1999;65:243–249
  3. Tavassoli FA. World Health Organization classification of tumors: pathology and genetics of tumors of the breast and female genital organs. Lyon, France: IARC Press; 2003;
  4. Ries LAG, Melbert D, Krapcho M, et al. Finding cancer statistics (Cancer stat fact sheets, cancer of the corpus and uterus, NOS). Bethesda, MD: National Cancer Institute http://seer.cancer.gov/statfacts/html/corp.html2008;Accessed March 31, 2008
  5. Bayer SR, DeCherney AH. Clinical manifestations and treatment of dysfunctional uterine bleeding. JAMA. 1993;269:1823–1828
  6. Coulter A, Bradlow J, Agass M, Martin-Bates C, Tulloch A. Outcomes of referrals to gynaecology outpatient clinics for menstrual problems: an audit of general practice records. Br J Obstet Gynaecol. 1991;98:789–796
  7. Shapiro AG. Emergency treatment of menstrual disorders in a nonpregnant woman. Emerg Med Clin North Am. 1987;5:559–568
  8. Coulter A, Klassen A, MacKenzie IZ, McPherson K. Diagnostic dilatation and curettage: is it used appropriately?. BMJ. 1993;306:236–239
  9. Hammond R, Johnson J. Endometrial hyperplasia. Curr Obstet Gynaecol. 2004;402:99–103
  10. American College of Obstetricians and Gynecologists. Management of endometrial cancer. ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005 Obstet Gynecol. 2005;106:413–425
  11. Epplein M, Reed SD, Voigt LF, Newton KW, Holt VL, Weiss NS. Endometrial hyperplasia risk in relation to characteristics and exposures that influence endogenous hormone levels. Am J Epidemiol. 2008;168:563–570discussion 571-6
  12. Gol K, Saracoglu F, Ekici A, Sahin I. Endometrial patterns and endocrinologic characteristics of asymptomatic menopausal women. Gynecol Endocrinol. 2001;15:63–67
  13. Korhonen MO, Symons JP, Hyde BM, Rowan JP, Wilborn WH. Histologic classification and pathologic findings for endometrial biopsy specimens obtained from 2964 perimenopausal and postmenopausal women undergoing screening for continuous hormones as replacement therapy (CHART 2 Study). Am J Obstet Gynecol. 1997;176:377–380
  14. Allison KH, Reed SD, Voigt LF, Jordan CD, Newton KM, Garcia RL. Diagnosing endometrial hyperplasia: why is it so difficult to agree?. Am J Surg Pathol. 2008;32:691–698
  15. United States National Institute on Aging. Estrogen use and postmenopausal women. NIH Consens Dev Conf Summ. 1979;2:1–5
  16. Baak JP, Nauta JJ, Wisse-Brekelmans EC, Bezemer PD. Architectural and nuclear morphometrical features together are more important prognosticators in endometrial hyperplasias than nuclear morphometrical features alone. J Pathol. 1988;154:335–341
  17. Baak JP, Wisse-Brekelmans EC, Fleege JC, van der Putten HW, Bezemer PD. Assessment of the risk on endometrial cancer in hyperplasia, by means of morphological and morphometrical features. Pathol Res Pract. 1992;188:856–859
  18. Bergeron C, Nogales FF, Masseroli M, et al. A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens. Am J Surg Pathol. 1999;23:1102–1108
  19. Burke TW, Tortolero-Luna G, Malpica A, et al. Endometrial hyperplasia and endometrial cancer. Obstet Gynecol Clin North Am. 1996;23:411–456
  20. Dietel M. The histological diagnosis of endometrial hyperplasia (Is there a need to simplify?). Virchows Arch. 2001;439:604–608
  21. Mutter GL, Baak JP, Crum CP, Richart RM, Ferenczy A, Faquin WC. Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry. J Pathol. 2000;190:462–469
  22. Kendall BS, Ronnett BM, Isacson C, et al. Reproducibility of the diagnosis of endometrial hyperplasia, atypical hyperplasia, and well-differentiated carcinoma. Am J Surg Pathol. 1998;22:1012–1019
  23. Skov BG, Broholm H, Engel U, et al. Comparison of the reproducibility of the WHO classifications of 1975 and 1994 of endometrial hyperplasia. Int J Gynecol Pathol. 1997;16:33–37
  24. Trimble CL, Kauderer J, Zaino R, et al. Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer. 2006;106:812–819
  25. Sivridis E, Giatromanolaki A. The endometrial hyperplasias revisited. Virch Arch. 2008;453:223–231
  26. Mutter GL, Zaino RJ, Baak JPA, Bentley RC, Robboy SJ. Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol. 2007;26:103–114
  27. Lacey JV, Mutter GL, Nucci MR, et al. Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsies. Cancer. 2008;113:2073–2081
  28. Whiteman MK, Hillis SD, Jamieson DJ, et al. Inpatient hysterectomy surveillance in the United States, 2000-2004. Am J Obstet Gynecol. 2008;198:34–37

 Reprints not available from the authors.

 This study was supported in part by Grant R01 HD044813-01 from the National Institute of Child Health and Human Development.

 The views expressed herein are those of the authors and do not necessarily represent the official views of National Institute of Child Health and Human Development.

 Cite this article as: Reed SD, Newton, KM; Clinton WL, et al. Incidence of endometrial hyperplasia. Am J Obstet Gynecol 2009;200:678.e1-678.e6.

PII: S0002-9378(09)00223-3

doi: 10.1016/j.ajog.2009.02.032

American Journal of Obstetrics & Gynecology
Volume 200, Issue 6 , Pages 678.e1-678.e6 , June 2009

Article Tools

* Image Usage & Resolution