American Journal of Obstetrics & Gynecology
Volume 200, Issue 6 , Pages 678.e1-678.e6, June 2009

Incidence of endometrial hyperplasia

Presented at the 75th Annual Meeting of the Pacific Coast Obstetrical and Gynecological Society, Victoria, BC, Canada, Oct. 15-19, 2008.

  • Susan D. Reed, MD, MPH

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
    • Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA
    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA
    • Center for Health Studies, Group Health, Seattle, WA
    • ,
  • Katherine M. Newton, PhD

      Affiliations

    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA
    • Center for Health Studies, Group Health, Seattle, WA
    • ,
  • Walter L. Clinton, PhD

      Affiliations

    • Center for Health Studies, Group Health, Seattle, WA
    • ,
  • Meira Epplein, PhD

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA
    • ,
  • Rochelle Garcia, MD

      Affiliations

    • Department of Pathology, University of Washington School of Medicine, Seattle, WA
    • ,
  • Kimberly Allison, MD

      Affiliations

    • Department of Pathology, University of Washington School of Medicine, Seattle, WA
    • ,
  • Lynda F. Voigt, PhD

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA
    • ,
  • Noel S. Weiss, DrPH, MD

      Affiliations

    • Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA
    • Department of Epidemiology, University of Washington School of Medicine, Seattle, WA

Received 23 August 2008; received in revised form 9 December 2008; accepted 26 February 2009. published online 24 April 2009.

Objective

The objective of the study was to estimate the age-specific incidence of endometrial hyperplasia: simple, complex, and atypical, in order of increasing likelihood of progression to carcinoma.

Study Design

Women aged 18-90 years with endometrial pathology specimens (1985-2003) at a large integrated health plan were identified using automated data. Incidence rates were obtained by dividing the number of cases by the estimated number of female health plan enrollees who retained a uterus.

Results

Endometrial hyperplasia peak incidence was: simple, 142 per 100,000 woman-years, complex, 213 per 100,000 woman-years, both in the early 50s; and atypical, 56 per 100,000 woman-years in the early 60s. Age-adjusted incidence decreased over the study period, especially for atypical hyperplasia.

Conclusion

Endometrial hyperplasia incidence without and with atypia peaks in the early postmenopausal years and in the early 60s, respectively. Given that some cases of endometrial hyperplasia likely go undiagnosed, the figures provided should be viewed as minimum estimates of the true incidence.

Key words: atypical endometrial hyperplasia, complex endometrial hyperplasia, incidence, simple endometrial hyperplasia

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 Reprints not available from the authors.

 This study was supported in part by Grant R01 HD044813-01 from the National Institute of Child Health and Human Development.

 The views expressed herein are those of the authors and do not necessarily represent the official views of National Institute of Child Health and Human Development.

 Cite this article as: Reed SD, Newton, KM; Clinton WL, et al. Incidence of endometrial hyperplasia. Am J Obstet Gynecol 2009;200:678.e1-678.e6.

PII: S0002-9378(09)00223-3

doi:10.1016/j.ajog.2009.02.032

American Journal of Obstetrics & Gynecology
Volume 200, Issue 6 , Pages 678.e1-678.e6, June 2009

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