American Journal of Obstetrics & Gynecology
Volume 201, Issue 1 , Pages 31.e1-31.e6, July 2009

Rapid human immunodeficiency virus testing in obstetric outpatient settings: the MIRIAD study

  • Naomi K. Tepper, MD, MPH

      Affiliations

    • Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Sherry L. Farr, MSPH, PhD

      Affiliations

    • Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Susan P. Danner, BA

      Affiliations

    • Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Robert Maupin, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Louisiana State University School of Medicine, New Orleans, LA
    • ,
  • Steven R. Nesheim, MD

      Affiliations

    • Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA
    • ,
  • Mardge H. Cohen, MD

      Affiliations

    • CORE Center, Stroger (formerly Cook County) Hospital, Chicago, IL
    • ,
  • Yvette A. Rivero, BA

      Affiliations

    • Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, FL
    • ,
  • Mayris P. Webber, DrPH

      Affiliations

    • Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY
    • ,
  • Marc Bulterys, MD, PhD

      Affiliations

    • CDC Global AIDS Program, Centers for Disease Control and Prevention, Beijing, China
    • ,
  • Michael K. Lindsay, MD, MPH

      Affiliations

    • Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA
    • ,
  • Denise J. Jamieson, MD, MPH

      Affiliations

    • Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA

Received 12 September 2008; received in revised form 1 December 2008; accepted 26 February 2009. published online 27 April 2009.

Objective

To evaluate the acceptability and feasibility of rapid human immunodeficiency virus testing in obstetric outpatient settings.

Study Design

The Mother-Infant Rapid Intervention at Delivery (MIRIAD) study was a prospective, multicenter study. Women were offered rapid and conventional human immunodeficiency virus testing if they presented to outpatient settings late in pregnancy with undocumented human immunodeficiency virus status. We compared median times between conventional and rapid testing and between rapid point-of-care and rapid laboratory-based testing.

Results

Among eligible women who were offered participation, 90% accepted testing. The median time from blood draw to result available was faster for rapid testing (25 minutes) than conventional testing (23 hours; P < .0001). For rapid tests, point-of-care testing was faster than laboratory-based testing (24 minutes vs 35 minutes; P < .0001). Almost 96% of rapid test results were available within 1 hour.

Conclusion

Rapid human immunodeficiency virus testing is acceptable, feasible, and provides results far sooner than conventional testing in obstetric outpatient settings.

Key words: human immunodeficiency virus, outpatient settings, rapid testing

 

 At the time of the study, Dr Nesheim was at the Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.

 This study was supported by the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), under cooperative agreements U64/217724, 417719, 517715, 617734, and 479935.

 Reprints not available from the authors.

 The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Use of trade names is for identification purposes only and does not constitute endorsement by the Centers for Disease Control and Prevention or the Department of Health and Human Services.

 Cite this article as: Tepper NK, Farr SL, Danner SP, et al. Rapid human immunodeficiency virus testing in obstetric outpatient settings: the MIRIAD study. Am J Obstet Gynecol 2009;201:31.e1-6.

PII: S0002-9378(09)00214-2

doi:10.1016/j.ajog.2009.02.023

American Journal of Obstetrics & Gynecology
Volume 201, Issue 1 , Pages 31.e1-31.e6, July 2009

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