American Journal of Obstetrics & Gynecology
Volume 201, Issue 1 , Pages 33.e1-33.e6, July 2009

Loop electrosurgical excision of the cervix and subsequent risk for spontaneous preterm delivery: a population-based study of singleton deliveries during a 9-year period

Presented at the 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China, Nov. 3-9, 2007.

  • Bugge Noehr, MD

      Affiliations

    • Institute of Cancer Epidemiology, Danish Cancer Society, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Allan Jensen, MSc, PhD

      Affiliations

    • Institute of Cancer Epidemiology, Danish Cancer Society, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Kirsten Frederiksen, MSc, PhD

      Affiliations

    • Institute of Cancer Epidemiology, Danish Cancer Society, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Ann Tabor, MD, DMSc

      Affiliations

    • Department of Fetal Medicine and Ultrasound, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Susanne K. Kjaer, MD, DMSc

      Affiliations

    • Institute of Cancer Epidemiology, Danish Cancer Society, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    • Department of Gynecology and Obstetrics, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark
    • Corresponding Author InformationReprints: Susanne Krüger Kjaer, MD, DMSc, Danish Cancer Society / Rigshospitalet, Strandboulevarden 49, DK-2100 Copenhagen, Denmark

Received 2 October 2008; received in revised form 8 December 2008; accepted 11 February 2009. published online 06 April 2009.

Objective

Our aim was to assess the association between loop electrosurgical excision procedure (LEEP) and the subsequent risk for spontaneous preterm delivery, with the use of population-based data from various nationwide registries.

Study Design

The study population consisted of all singleton deliveries in Denmark during a 9-year period, 1997-2005. Information on the deliveries that included different cervical procedures was obtained from various national registries. In all, 552,678 deliveries were eligible for analyses.

Results

Of the deliveries in which the mother had no previous LEEP, 18,519 deliveries (3.5%) were preterm; when this data were applied to 530 preterm deliveries (6.9%) that were subsequent to LEEP, the yield was a significantly increased risk of preterm delivery, with an odds ratio of 2.07 (95% CI, 1.88-2.27; LEEP vs no LEEP).

Conclusion

Our study showed an overall 2-fold increase in the risk of spontaneous preterm delivery in singleton deliveries subsequent to LEEP treatment, even after adjustment for various potential risk factors.

Key words: loop electrosurgical excision procedure, preterm delivery

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 Authorship and contribution to the manuscript is limited to the 5 authors indicated. There was no outside funding or technical assistance with the production of this article.

 Cite this article as: Noehr B, Jensen A, Frederiksen K, et al. Loop electrosurgical excision of the cervix and subsequent risk for spontaneous preterm delivery: a population-based study of singleton deliveries during a 9-year period. Am J Obstet Gynecol 2009;201:33.e1-6.

PII: S0002-9378(09)00189-6

doi:10.1016/j.ajog.2009.02.004

American Journal of Obstetrics & Gynecology
Volume 201, Issue 1 , Pages 33.e1-33.e6, July 2009

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