American Journal of Obstetrics & Gynecology
Volume 200, Issue 5 , Pages 499.e1-499.e6 , May 2009

Predictive value of combined amniotic fluid proteomic biomarkers and interleukin-6 in preterm labor with intact membranes

  • Teresa Cobo, MD

      Affiliations

    • Department of Maternal-Fetal Medicine, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • ,
  • Montse Palacio, MD

      Affiliations

    • Department of Maternal-Fetal Medicine, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • CIBER de Enfermedades Raras (CIBERER), Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • ,
  • Aleix Navarro-Sastre, MD

      Affiliations

    • Department of Biochemistry and Molecular Genetics, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • CIBER de Enfermedades Raras (CIBERER), Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • ,
  • Antonia Ribes, MD

      Affiliations

    • Department of Biochemistry and Molecular Genetics, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • CIBER de Enfermedades Raras (CIBERER), Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • ,
  • Jordi Bosch, MD

      Affiliations

    • Department of Microbiology, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • ,
  • Xavier Filella, MD

      Affiliations

    • Department of Biochemistry and Molecular Genetics, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • ,
  • Eduard Gratacós, MD

      Affiliations

    • Department of Maternal-Fetal Medicine, Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain
    • CIBER de Enfermedades Raras (CIBERER), Institut de Investigacions Biomèdiques August Pi-Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain

Received 3 June 2008 ,Revised 22 September 2008 ,Accepted 22 December 2008.

References 

  1. Romero R, Espinoza J, Goncalves LF, Kusanovic JP, Friel L, Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007;25:21–39
  2. Yoon BH, Romero R, Moon JB, et al. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2001;185:1130–1136
  3. Romero R, Yoon BH, Mazor M, et al. The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and Gram stain in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 1993;169:805–816
  4. Coultrip LL, Lien JM, Gomez R, Kapernick P, Khoury A, Grossman JH. The value of amniotic fluid interleukin-6 determination in patients with preterm labor and intact membranes in the detection of microbial invasion of the amniotic cavity. Am J Obstet Gynecol. 1994;171:901–911
  5. Buhimschi CS, Weiner CP, Buhimschi IA. Clinical proteomics: a novel diagnostic tool for the new biology of preterm labor, part I: proteomics tools. Obstet Gynecol Surv. 2006;61:481–486
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  8. Buhimschi CS, Bhanderi V, Hamar BD, et al. Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis. PLoS Med. 2007;4:e18
  9. Gibbs RS, Blanco JA, St Clair PJ, Castaneda YS. Quantitative bacteriology of amniotic fluid from women with clinical intraamniotic infection at term. J Infect Dis. 1982;145:1–8
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  11. Lee SD, Kim MR, Hwang PG, Shim SS, Yoon BH, Kim CJ. Chorionic plate vessels as an origin of amniotic fluid neutrophils. Pathol Int. 2004;54:516–522
  12. Buhimschi CS, Buhimschi IA, Abdel-Razeq S, et al. Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. Pediatr Res. 2007;61:318–324
  13. Romero R, Yoon BH, Mazor M, et al. A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes. Am J Obstet Gynecol. 1993;169:839–851
  14. Vogel I, Thorsen P, Curry A, Sandager P, Uldbjerg N. Biomarkers for the prediction of preterm delivery. Acta Obstet Gynecol Scand. 2005;84:516–525
  15. Buhimschi CS, Weiner CP, Buhimschi IA. Proteomics, part II: the emerging role of proteomics over genomics in spontaneous preterm labor/birth. Obstet Gynecol Surv. 2006;61:543–553
  16. Klein LL, Freitag BC, Gibbs RS, Reddy AP, Nagalla SR, Gravett MG. Detection of intra-amniotic infection in a rabbit model by proteomics-based amniotic fluid analysis. Am J Obstet Gynecol. 2005;193:1302–1306

 Reprints not available from the authors.

 Cite this article as: Cobo T, Palacio M, Navarro-Sastre A, et al. Predictive value of combined amniotic fluid proteomic biomarkers and interleukin-6 in preterm labor with intact membranes. Am J Obstet Gynecol 2009;200:499.e1-499.e6.

PII: S0002-9378(08)02443-5

doi: 10.1016/j.ajog.2008.12.036

American Journal of Obstetrics & Gynecology
Volume 200, Issue 5 , Pages 499.e1-499.e6 , May 2009

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