American Journal of Obstetrics & Gynecology
Volume 200, Issue 3 , Pages 331.e1-331.e5, March 2009

Glycine absorption in operative hysteroscopy: the impact of anesthesia

Presented at the 75th Annual Meeting of the Central Association of Obstetricians and Gynecologists, New Orleans, LA, Oct. 22-25, 2008.

  • Marie-Ève Bergeron, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Faculty of Medicine, Université Laval, Québec City, QC, Canada
  • ,
  • Christine Beaudet, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Faculty of Medicine, Université Laval, Québec City, QC, Canada
  • ,
  • Emmanuel Bujold, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Faculty of Medicine, Université Laval, Québec City, QC, Canada
  • ,
  • Caroline Rhéaume, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Faculty of Medicine, Université Laval, Québec City, QC, Canada
  • ,
  • Pascale Ouellet, MD

      Affiliations

    • Department of Anesthesiology, Centre Hospitalier Universitaire de Québec, Faculty of Medicine, Université Laval, Québec City, QC, Canada
  • ,
  • Philippe Laberge, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Faculty of Medicine, Université Laval, Québec City, QC, Canada
    • Corresponding Author InformationReprints: Philippe Laberge, MD, Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, 2705 Boulevard Laurier, Québec City, Québec, Canada

Received 1 July 2008; received in revised form 13 November 2008; accepted 20 December 2008.

Objective

This study aimed to evaluate the impact of anesthesia on the absorption of glycine in operative hysteroscopy.

Study Design

A retrospective cohort study was performed over 2 years. The absorption of glycine was compared among general anesthesia, local anesthesia with intravenous sedation, and spinal anesthesia. Multiple logistic regression analyses were performed.

Results

In all, 282 operative hysteroscopies were reviewed. The median absorption was 145 mL (10th-90th centile: 0-963 mL) for general anesthesia, 35 mL (10th-90th centile: 0-389 mL) for local anesthesia, and 100 mL (10th-90th centile: 0-500 mL) for spinal anesthesia (P = .002). In comparison with general anesthesia, local anesthesia was associated with lower rate of absorption of 500-1000 mL (4.2% vs 13.4%) and of 1000-1500 mL (3.6% vs 9.8; P = .002). Laparoscopic tubal ligation performed during the procedure was also associated with higher glycine absorption (odds ratio, 3.63; 95% confidence interval, 1.12-11.84).

Conclusions

Local anesthesia with sedation is associated with significantly decreased glycine absorption and lower rate of absorption > 500 mL when compared with general anesthesia.

Key words: endometrial resection, general anesthesia, glycine absorption, local anesthesia and intravenous sedation, operative hysteroscopy

 

 Cite this article as: Bergeron M-È, Beaudet C, Bujold E, et al. Glycine absorption in operative hysteroscopy: the impact of anesthesia. Am J Obstet Gynecol 2009;200:331.e1-331.e5.

PII: S0002-9378(08)02430-7

doi:10.1016/j.ajog.2008.12.024

American Journal of Obstetrics & Gynecology
Volume 200, Issue 3 , Pages 331.e1-331.e5, March 2009