American Journal of Obstetrics & Gynecology
Volume 200, Issue 3 , Pages 338.e1-338.e4 , March 2009

Yolk sac on transvaginal ultrasound as a prognostic indicator in the treatment of ectopic pregnancy with single-dose methotrexate

Presented at the 75th Annual Meeting of the Central Association of Obstetricians and Gynecologists, New Orleans, LA, Oct. 22-25, 2008.

Received 1 July 2008 ,Revised 10 November 2008 ,Accepted 5 December 2008.

References 

  1. Kooi S, Kock HC. A review of the literature on nonsurgical treatment in tubal pregnancies. Obstet Gynecol Surv. 1992;47:739–749
  2. Glock JL, Johnson JV, Brumsted JR. Efficacy and safety of single-dose systemic methotrexate in the treatment of ectopic pregnancy. Fertil Steril. 1994;62:716–721
  3. Ransom MX, Garcia AJ, Bohrer M, Corsan GH, Kemmann E. Serum progesterone as a predictor of methotrexate success in the treatment of ectopic pregnancy. Obstet Gynecol. 1994;83:1033–1037
  4. Corsan GH, Karacan M, Qasim S, Bohrer MK, Ransom MX, Kemmann E. Identification of hormonal parameters for successful systemic single-dose methotrexate therapy in ectopic pregnancy. Hum Reprod. 1995;10:2719–2722
  5. Shalev E, Peleg D, Bustan M, Romano S, Tsabari A. Limited role for intratubal methotrexate treatment of ectopic pregnancy. Fertil Steril. 1995;63:20–24
  6. Stika CS, Anderson L, Frederiksen MC. Single-dose methotrexate for the treatment of ectopic pregnancy: Northwestern Memorial Hospital three-year experience. Am J Obstet Gynecol. 1996;174:1840–1846
  7. Lipscomb GH, McCord ML, Stovall TG, Huff G, Portera SG, Ling FW. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med. 1999;341:1974–1978
  8. Lipscomb GH, Givens VA, Meyer ML, Bran D. Previous ectopic pregnancy as a risk factor for failure of systemic methotrexate therapy. Fertil Steril. 2004;81:1221–1224
  9. Bixby S, Tello R, Kuligowska E. Presence of a yolk sac on transvaginal sonography is the most reliable predictor of single-dose methotrexate treatment failure in ectopic pregnancy. J Ultrasound Med. 2005;24:591–598
  10. Potter MB, Lepine LA, Jamieson DJ. Predictors of success with methotrexate treatment of tubal ectopic pregnancy at Grady Memorial Hospital. Am J Obstet Gynecology. 2003;188:1192–1194
  11. Stovall TG, Ling FW, Carson SA, Buster JE. Nonsurgical diagnosis and treatment of tubal pregnancy. Fertil Steril. 1990;54:537–538
  12. Stovall TG, Ling FW, Gray LA, Carson SA, Buster JE. Methotrexate treatment of unruptured ectopic pregnancy: a report of 100 cases. Obstet Gynecol. 1991;77:749–753
  13. Stovall TG, Ling FW. Single-dose methotrexate: an expanded clinical trial. Am J Obstet Gynecol. 1993;168:1759–1762

 Cite this article as: Lipscomb GH, Gomez IG, Givens VM, et al. Yolk sac on transvaginal ultrasound as a prognostic indicator in the treatment of ectopic pregnancy with single-dose methotrexate. Am J Obstet Gynecol 2009;200:338.e1-338.e4.

 Reprints not available from the authors.

PII: S0002-9378(08)02346-6

doi: 10.1016/j.ajog.2008.12.006

American Journal of Obstetrics & Gynecology
Volume 200, Issue 3 , Pages 338.e1-338.e4 , March 2009