American Journal of Obstetrics & Gynecology
Volume 200, Issue 4 , Pages 417.e1-417.e5 , April 2009

Ultrasound imaging after evacuation as an adjunct to β-hCG monitoring in posthydatidiform molar gestational trophoblastic neoplasia

Received 8 August 2008 ,Revised 25 September 2008 ,Accepted 17 November 2008.

References 

  1. Berkowitz RS, Goldstein DP. Presentation and management of molar pregnancy. In:  Hancock BW,  Newlands ES,  Berkowitz RS editor. Gestational trophoblastic disease. London: Chapman and Hall; 1997;p. 127–146
  2. Seckl MJ, Fisher RA, Salerno G, et al. Choriocarcinoma and partial hydatidiform moles. Lancet. 2000;356:36–39
  3. Ngan S, Seckl MJ. Gestational trophoblastic neoplasia management: an update. Curr Opin Oncol. 2007;19:486–491
  4. Morrow CP. Postmolar trophoblastic disease: diagnosis, management, and prognosis. Clin Obstet Gynecol. 1984;27:211–220
  5. Kim SJ, Na YJ, Jung SG, Kim CJ, Bae SN, Lee C. Management of high-risk hydatidiform mole and persistent gestational trophoblastic neoplasia: the Korean experience. J Reprod Med. 2007;52:819–830
  6. Goldstein DP, Berkowitz RS, Bernstein MR. Management of molar pregnancy. J Reprod Med. 1981;26:208–212
  7. Lurain JR, Brewer JI, Torok EE, Halpern B. Natural history of hydatidiform mole after primary evacuation. Am J Obstet Gynecol. 1983;145:591–595
  8. Niemann I, Petersen LK, Hansen ES, Sunde L. Predictors of low risk of persistent trophoblastic disease in molar pregnancies. Obstet Gynecol. 2006;107:1006–1011
  9. Berkowitz RS, Goldstein DP. Chorionic tumors. N Engl J Med. 1996;335:1740–1748
  10. Tow WS. The influence of the primary treatment of hydatidiform mole on its subsequent course. J Obstet Gynaecol Br Commonw. 1966;73:544–552
  11. Tsukamoto N, Iwasaka T, Kashimura Y, Uchino H, Kashimura M, Matsuyama T. Gestational trophoblastic disease in women aged 50 or more. Gynecol Oncol. 1985;20:53–61
  12. Xia ZF, Song HZ, Tang MY. Risk of malignancy and prognosis using a provisional scoring system in hydatidiform mole. Chin Med J (Engl). 1980;93:605–612
  13. Ayhan A, Tuncer ZS, Halilzade H, Küçükali T. Predictors of persistent disease in women with complete hydatidiform mole. J Reprod Med. 1996;41:591–594
  14. Stone M, Bagshawe KD. An analysis of the influences of maternal age, gestational age, contraceptive method, and the mode of primary treatment of patients with hydatidiform moles on the incidence of subsequent chemotherapy. BJOG. 1979;86:782–792
  15. Feltmate CM, Growdon WB, Wolfberg AJ, et al. Clinical characteristics of persistent gestational trophoblastic neoplasia after partial hydatidiform molar pregnancy. J Reprod Med. 2006;51:902–906
  16. Berkowitz RS, Bernstein MR, Laborde O, Goldstein DP. Subsequent pregnancy experience in patients with gestational trophoblastic disease: New England Trophoblastic Disease Center, 1965-1992. J Reprod Med. 1994;39:228–232
  17. Seckl MJ, Dhillon T, Dancey G, et al. Increased gestational age at evacuation of a complete hydatidiform mole: does it correlate with increased risk of requiring chemotherapy?. J Reprod Med. 2004;49:527–530
  18. Parazzini F, Mangili G, Belloni C, La Vecchia C, Liati P, Marabini R. The problem of identification of prognostic factors for persistent trophoblastic disease. Gynecol Oncol. 1988;30:57–62
  19. Parazzini F, La Vecchia C, Franceschi S, et al. ABO blood-groups and the risk of gestational trophoblastic disease. Tumori. 1985;71:123–126
  20. Curry SL, Hammond CB, Tyrey L, Creasman WT, Parker RT. Hydatidiform mole: diagnosis, management, and long-term follow-up of 347 patients. Obstet Gynecol. 1975;45:1–8
  21. Berkowitz RS, Goldstein DP, DuBeshter B, Bernstein MR. Management of complete molar pregnancy. J Reprod Med. 1987;32:634–639
  22. Berkowitz R, Ozturk M, Goldstein D, Bernstein M, Hill L, Wands JR. Human chorionic gonadotropin and free subunits' serum levels in patients with partial and complete hydatidiform moles. Obstet Gynecol. 1989;74:212–216
  23. Benedet JL, Bender H, Jones H, Ngan HY, Pecorelli S. FIGO staging, classification, and clinical practice guidelines in the management of gynecologic cancers: FIGO Committee on Gynecologic Oncology. Int J Gynecol Obstet. 2000;70:209–262
  24. Mangili G, Garavaglia E, Cavoretto P, Gentile C, Scarfone G, Rabaiotti E. Clinical presentation of hydatidiform mole in northern Italy: has it changed in the last 20 years?. Am J Obstet Gynecol. 2008;198:302.e1–302.e4
  25. Sebire NJ, Foskett M, Short D, et al. Shortened duration of human chorionic gonadotrophin surveillance after complete or partial hydatidiform mole: evidence for revised protocol of a UK regional trophoblastic disease unit. BJOG. 2007;114:760–762

 Cite this article as: Garavaglia E, Gentile C, Cavoretto P, Spagnolo D, Valsecchi, Mangili G. Ultrasound imaging after evacuation as an adjunct to β-hCG monitoring in posthydatidiform molar gestational trophoblastic neoplasia. Am J Obstet Gynecol 2009;200:417.e1-417.e5.

 Authorship and contribution to the article is limited to the 6 authors indicated. There was no outside funding or technical assistance with the production of this article.

PII: S0002-9378(08)02270-9

doi: 10.1016/j.ajog.2008.11.032

American Journal of Obstetrics & Gynecology
Volume 200, Issue 4 , Pages 417.e1-417.e5 , April 2009