American Journal of Obstetrics & Gynecology
Volume 200, Issue 2 , Pages 130-135, February 2009

Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies

  • Francesca Bravi, ScD

      Affiliations

    • Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
    • Istituto di Statistica Medica e Biometria “G.A. Maccacaro”, Università degli Studi di Milano, Milan, Italy
    • Corresponding Author InformationReprints: Francesca Bravi, ScD, Istituto di Ricerche Farmacologiche “Mario Negri,” Dipartimento di Epidemiologia, Via Giuseppe La Masa 19-20156 Milan MI, Italy
    • ,
  • Lorenza Scotti, ScD

      Affiliations

    • Dipartimento di Statistica, Università di Milano Bicocca, Italy
    • ,
  • Cristina Bosetti, ScD

      Affiliations

    • Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
    • ,
  • Silvano Gallus, ScD

      Affiliations

    • Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
    • ,
  • Eva Negri, ScD

      Affiliations

    • Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
    • ,
  • Carlo La Vecchia, MD

      Affiliations

    • Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
    • Istituto di Statistica Medica e Biometria “G.A. Maccacaro”, Università degli Studi di Milano, Milan, Italy
    • ,
  • Alessandra Tavani, ScD

      Affiliations

    • Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy

Received 20 June 2008; received in revised form 23 September 2008; accepted 7 October 2008. published online 29 December 2008.

We conducted a metaanalysis of published studies on the relation between coffee drinking and endometrial cancer risk, which included 2 cohort (201 cases) and 7 case-control studies (2409 cases). The summary relative risk (RR) for coffee drinkers vs nondrinkers was 0.80 (95% confidence interval [CI], 0.68-0.94), with significant heterogeneity between studies. Compared with nondrinkers, the summary RR was 0.87 (95% CI, 0.78-0.97) for low-to-moderate coffee drinkers and 0.64 (95% CI, 0.48-0.86) for heavy coffee drinkers. The summary RR for an increase of 1 cup/d was 0.93 (95% CI, 0.89-0.97), which suggests an inverse relation between coffee and endometrial cancer. However, the causality must be confirmed.

Key words: coffee, endometrial cancer, metaanalysis, risk factor

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 This work was conducted with the contribution of the Italian Association for Cancer Research, and the Italian League Against Cancer. The work of this paper was undertaken while CLV was a Senior Fellow at the International Agency for Research on Cancer (IARC).

 Authorship and contribution to the manuscript is limited to the 7 authors indicated. There was no outside funding or technical assistance with the production of this article.

PII: S0002-9378(08)02044-9

doi:10.1016/j.ajog.2008.10.032

American Journal of Obstetrics & Gynecology
Volume 200, Issue 2 , Pages 130-135, February 2009

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