American Journal of Obstetrics & Gynecology
Volume 200, Issue 5 , Pages e24-e26, May 2009

Rectal misoprostol vs 15-methyl prostaglandin F2α for retained placenta after second-trimester delivery

Presented at the 55th Annual Clinical Meeting of The American College of Obstetricians and Gynecologists, San Diego, CA, May 5-9, 2007.

Department of Obstetrics and Gynecology, University of Miami, Miller School of Medicine, Miami, FL

Received 6 July 2008; received in revised form 19 September 2008; accepted 26 September 2008. published online 12 January 2009.

Objective

The purpose of this study was to compare rectal misoprostol (RM) with 15-methyl prostaglandin F2α (PGF2α) for the management of retained placenta after second-trimester deliveries.

Study Design

A retrospective study of all second-trimester deliveries between the years 2000 and 2005 was performed. Women were divided into 2 groups, depending on whether they received RM or PGF2α after the delivery.

Results

Three hundred three second-trimester deliveries were analyzed. The time from the administration of medications to the placental delivery was significantly shorter in women who received PGF2α, compared with the RM group (49.5 vs 89 minutes; P < .01). Women who received PGF2α had lower rates of retained placenta (4.9% vs 12.4%; P = .02).

Conclusion

The use of PGF2α after second-trimester deliveries results in shorter third stage of labor and lower rates of retained placenta compared with RM.

Key words: misoprostol, prostaglandin F2α, retained placenta, second-trimester delivery

 

 Authorship and contribution to the article is limited to the 4 authors indicated. There was no outside funding or technical assistance with the production of this article.

PII: S0002-9378(08)01093-4

doi:10.1016/j.ajog.2008.09.868

American Journal of Obstetrics & Gynecology
Volume 200, Issue 5 , Pages e24-e26, May 2009

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