Evaluation of mifepristone as a once a month contraceptive pill

Objective

The purpose of this study was to assess the efficacy and safety of mifepristone as a contraceptive pill.

Study Design

A prospective case-control study was conducted in a tertiary care center of North India. The study group (n = 86) was given 200-mg mifepristone tablets on the 16th day of the menstrual cycle. The control group (n = 92) received combined oral contraceptive (COC) as per protocol. Subjects were followed for drug compliance, satisfaction, side effects, and failure.

Results

Acceptability of mifepristone was significantly higher in educated population (P < .001), with fewer side effects (P = .001), good satisfaction (P < .001), and higher compliance rate (P = .05). The oral contraceptive pill group had higher adverse biochemical parameters.

Conclusion

Mifepristone can be used as a monthly contraceptive pill effectively.

Key words: contraceptive pill, mifepristone, monthly