American Journal of Obstetrics & Gynecology
Volume 200, Issue 2 , Pages 175.e1-175.e5 , February 2009

Concurrent cisplatin-based chemoradiation International Federation of Gynecology and Obstetrics stage IB2 cervical carcinoma

  • Behiye P.C. Goksedef, MD

      Affiliations

    • Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH
  • ,
  • Charles Kunos, MD, PhD

      Affiliations

    • Department of Radiation Oncology, University Hospitals of Cleveland, Cleveland, OH
  • ,
  • Jerome L. Belinson, MD

      Affiliations

    • Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH
  • ,
  • Peter G. Rose, MD

      Affiliations

    • Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH
    • Department of Obstetrics and Gynecology, MetroHealth Medical Center, Cleveland, OH
    • Corresponding Author InformationReprints: Peter G. Rose, MD, Section of Gynecologic Oncology, Department of Obstetrics and Gynecology/A81, 9500 Euclid Ave, Cleveland, OH 44195

Received 2 May 2008 ,Revised 14 July 2008 ,Accepted 30 August 2008.

References 

  1. Delgado G, Bundy B, Fowler WC, et al. A prospective surgical pathological study of stage 1 squamous carcinoma of the cervix: a gynecologic group study. Gynecol Oncol. 1989;35:314–320
  2. Yessaian A, Magistris A, Burger RA, Monk BJ. Radical hysterectomy followed by tailored postoperative therapy in the treatment of stage 1B2 cervical cancer: feasibility and indications for adjuvant therapy. Gynecol Oncol. 2004;94:61–66
  3. Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage 1B cervical carcinoma. N Engl J Med. 1999;340:1154–1161
  4. Keys HM, Bundy BN, Stehman FB, et al. Radiation therapy with or without extrafascial hysterectomy for bulky stage IB cervical carcinoma: a randomized trial of the Gynecologic Oncology Group. Gynecol Oncol. 2003;89:343–353
  5. Stehman FB, Ali S, Keys HM, et al. Radiation therapy with or without weekly cisplatin for bulky stage 1B cervical carcinoma: follow-up of a Gynecologic Oncology Group trial. Am J Obstet Gynecol. 2007;197:503.e1–503.e6
  6. Benedetti-Panici P, Greggi S, Colombo A, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. J Clin Oncol. 2002;20:179–188
  7. Eddy GL, Bundy BN, Creasman WT, et al. Treatment of (‘bulky') stage 1B cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical hysterectomy and pelvic/para-aortic lymphadenectomy: a phase III trial of the gynecologic oncology group. Gynecol Oncol. 2007;106:362–369
  8. Blessing JA. Design, analysis and interpretation of chemotherapy trials in gynecologic cancer. In:  Deppe G editors. Chemotherapy of gynecologic cancer. 2nd ed.. New York: Alan R. Liss; 1990;p. 63–97
  9. Sedlis A, Bundy BN, Rotman MZ, Lentz SS, Muderspach LI, Zaino RJ. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a gynecologic oncology study. Gynecol Oncol. 1999;73:177–183
  10. Rotman M, Sedlis A, Piedmonte MR, et al. A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features: follow up of a Gynecologic Oncology Group study. Int J Radiat Oncol Biol Phys. 2006;65:169–176
  11. Peters WA, Liu PY, Barrett RJ, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high risk early stage cancer of the cervix. J Clin Oncol. 2000;18:1608–1613
  12. Monk BJ, Wang J, Im S, et al. Rethinking the use of radiation and chemotherapy after radical hysterectomy: a clinical- pathologic analysis of a Gynecologic Oncology Group/Southwest Oncology Group/Radiation Therapy Oncology Group Trial. Gynecol Oncol. 2005;96:721–728
  13. Mendenhall WWM, McCarty PJ, Morgan LS, Chafe WE, Million RR. Stage IB or IIA- B of the intact uterine cervix ≥ 6 cm in diameter: is the adjuvant extrafacial hysterectomy beneficial?. Int J Radiation Oncology Biol Phys. 1991;21:899–904
  14. Barter JF, Soong SJ, Shingleton HM, Hatch KD, Orr JW. Complications of combined radical hysterectomy-postoperative radiation therapy in women with early stage cervical cancer. Gynecol Oncol. 1989;32:292–296
  15. Sardi JE, Giaroli A, Sananes C, et al. Long term follow up of the first randomized trial using neoadjuvant chemotherapy in stage 1B squamous carcinoma of the cervix: Final results. Gynecol Oncol. 1997;67:61–69
  16. Namkoong SE, Park JS, Kim JW, et al. Comparative study of the patients with locally advanced stage I and II cervical cancer treated by radical surgery with and without preoperative adjuvant chemotherapy. Gynecol Oncol. 1995;59:136–142
  17. Landoni F, Maneo A, Colombo A, et al. Randomized study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 1997;350:535–540
  18. Holtz DO, Dunton C. Traditional management of invasive cervical cancer. Obstet Gynecol Clin North Am. 2002;29:645–657
  19. Darus CJ, Callahan MB, Nguyen Q-N, et al. Chemoradiation with and without adjuvant extrafascial hysterectomy for IB2 cervical carcinoma. http://www.blackwell-synergy.com/doi/abs/10.1111/j.1525-1438.2007.01095.xAccessed June 20, 2008.
  20. Choi CH, Kim TJ, Lee JW, Kim BG, Lee JH, Bae DS. Phase II study of neoadjuvant chemotherapy with mitomycin-c, vincristine and cisplatin (MVC) in patients with stages IB2-IIb cervical carcinoma. Gynecol Oncol. 2007;104:64–69

 Cite this article as: Goksedef BPC, Kunos C, Belinson JL, et al. Concurrent cisplatin-based chemoradiation International Federation of Gynecology and Obstetrics stage IB2 cervical carcinoma. Am J Obstet Gynecol 2009;200:175.e1-175.e5.

PII: S0002-9378(08)01024-7

doi: 10.1016/j.ajog.2008.08.055

American Journal of Obstetrics & Gynecology
Volume 200, Issue 2 , Pages 175.e1-175.e5 , February 2009