American Journal of Obstetrics & Gynecology
Volume 200, Issue 2 , Pages 158.e1-158.e6 , February 2009

Fetal fibronectin testing in patients with short cervix in the midtrimester: can it identify optimal candidates for ultrasound-indicated cerclage?

  • Sean M. Keeler, MD

      Affiliations

    • Department of Obstetrics and Gynecology, New York University Medical Center, New York, NY
    • ,
  • Ashley S. Roman, MD, MPH

      Affiliations

    • Department of Obstetrics and Gynecology, New York University Medical Center, New York, NY
    • ,
  • Jaclyn M. Coletta, MD

      Affiliations

    • Department of Obstetrics and Gynecology, New York University Medical Center, New York, NY
    • ,
  • Daniel G. Kiefer, MD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Medicine, Stony Brook University School of Medicine, Stony Brook, NY
    • ,
  • Martin Feuerman, MS

      Affiliations

    • Department of Academic Affairs, Winthrop University Hospital, Mineola, NY
    • ,
  • Orion A. Rust, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Lehigh Valley Hospital, Allentown, PA

Received 16 June 2008 ,Accepted 20 August 2008.

References 

  1. Berghella V, Odibo AO, Tolosa JE. Cerclage for prevention of preterm birth in women with short cervix found on transvaginal ultrasound examination: a randomized trial. Am J Obstet Gynecol. 2004;191:1311–1317
  2. To MS, Alfirevic Z, Heath VCF, et al. Cervical cerclage for prevention of preterm delivery in women with short cervix: randomised controlled trial. Lancet. 2004;363:1849–1853
  3. Iams JD, Goldenberg RL, Meis PJ, et al. The length of the cervix and the risk of spontaneous premature delivery: National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. N Engl J Med. 1996;334:567–572
  4. Owen J, Yost N, Berghella V, et al. Mid-trimester endovaginal sonography in women at high risk for spontaneous preterm birth. JAMA. 2001;286:1340–1348
  5. Goldenberg RL, Iams JD, Das D, et al. The preterm prediction study: sequential cervical length and fetal fibronectin testing for the prediction of spontaneous preterm birth. Am J Obstet Gynecol. 2000;182:636–643
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  12. Rust OA, Atlas RO, Reed J, van Gaalen J, Balducci J. Revisiting the short cervix detected by transvaginal ultrasound in the second trimester: why cerclage therapy may not help. Am J Obstet Gynecol. 2001;185:1098–1105
  13. Roman AS, Rebarber A, Sfakianaki AK, et al. Vaginal fetal fibronectin as a predictor of spontaneous preterm delivery in the patient with cervical cerclage. Am J Obstet Gynecol. 2003;189:1368–1373
  14. Rust OA, Atlas RO, Jones KJ, Benham BN, Balducci J. A randomized trial of cerclage versus no cerclage among patients with ultrasonographically detected second-trimester preterm dilatation of the internal os. Am J Obstet Gynecol. 2000;183:830–835
  15. Rust O, Larkin R, Roberts W, et al. A randomized controlled trial of cerclage versus 17-hydroxyprogesterone (17P) for the treatment of short cervix. Am J Obstet Gynecol. 2007;195:S112
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  17. Lindquist K. SAS FAQ: How to estimate relative risk in SAS using PROC GENMOD for common outcomes in cohort studies. http://www.ats.ucla.edu/stat/sas/faq/relative_risk.htmAccessed February 5, 2008
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 Cite this article as: Keeler SM, Roman AS, Coletta JM, et al. Fetal fibronectin testing in patients with short cervix in the midtrimester: can it identify optimal candidates for ultrasound-indicated cerclage? Am J Obstet Gynecol 2009;200:158.e1-158.e6.

 Reprints not available from the authors.

PII: S0002-9378(08)00986-1

doi: 10.1016/j.ajog.2008.08.050

American Journal of Obstetrics & Gynecology
Volume 200, Issue 2 , Pages 158.e1-158.e6 , February 2009

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