American Journal of Obstetrics & Gynecology
Volume 200, Issue 1 , Pages 100.e1-100.e8, January 2009

Cord immunoproteins as predictors of respiratory outcome in preterm infants

  • Tuula Kaukola, MD

      Affiliations

    • Department of Pediatrics, Faculty of Medicine, University of Oulu, Oulu, Finland
    • ,
  • Jarno Tuimala, PhD

      Affiliations

    • Finnish IT Center for Science, Espoo, Finland
    • ,
  • Riitta Herva, MD

      Affiliations

    • Department of Pathology, Faculty of Medicine, University of Oulu, Oulu, Finland
    • ,
  • Stephen Kingsmore, MD

      Affiliations

    • National Center for Genome Resources, Santa Fe, NM
    • ,
  • Mikko Hallman, MD

      Affiliations

    • Department of Pediatrics, Faculty of Medicine, University of Oulu, Oulu, Finland

Received 25 February 2008; received in revised form 5 May 2008; accepted 28 July 2008. published online 25 November 2008.

Objective

The purpose of this study was to evaluate the role of cord blood proteins and antenatal factors in the prediction of respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD).

Study Design

The prospectively collected cohort included 163 infants. All infants were born between 1998-2002 in a single regional hospital before 32 weeks of gestation and survived the first hospitalization. Altogether, 107 cord blood proteins were analyzed. Twenty-two antenatal clinical factors were included in the data mining and logistic regression analyses.

Results

The incidence of RDS was 64% and of BPD was 25%. Histologic chorioamnionitis protected from RDS (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11-0.53; P < .001). Besides the length of gestation, other clinical factors poorly predicted the outcomes. Matrix metalloproteinase-9 independently predicted RDS (OR, 8.3; 95% CI, 3.0-23.1; P < .001). Soluble glycoprotein 130 independently predicted BPD (OR, 6.07; 95%CI, 2.20-16.7; P < .001).

Conclusion

Specific antenatal immunologic activation predicts either acute or chronic respiratory disease in very preterm infants.

Key words: bronchopulmonary dysplasia, cytokines, immunoproteins in cord blood, preterm birth, respiratory distress syndrome

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 This study was supported by the Foundation for Pediatric Research and by the Alma and K. A. Snellman Foundation, Oulu, Finland.

 Cite this article as: Kaukola T, Tuimala J, Herva R, et al. Cord immunoproteins as predictors of respiratory outcome in preterm infants. Am J Obstet Gynecol 2009;200:100.e1-100.e8.

 Reprints not available from the authors.

PII: S0002-9378(08)00917-4

doi:10.1016/j.ajog.2008.07.070

American Journal of Obstetrics & Gynecology
Volume 200, Issue 1 , Pages 100.e1-100.e8, January 2009

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