American Journal of Obstetrics & Gynecology
Volume 199, Issue 4 , Pages 378.e1-378.e6 , October 2008

Can myometrial electrical activity identify patients in preterm labor?

Presented at the 28th Annual Meeting of the Society for Maternal-Fetal Medicine, Dallas, TX, Jan. 28-Feb. 2, 2008.

  • Orli Most, MD

      Affiliations

    • Department of Obstetrics and Gynecology, New York University Medical Center, New York, NY
    • Corresponding Author InformationReprints: Orli Most, MD, Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, 1000 Tenth Ave, Suite 10C, New York, NY 10019
  • ,
  • Oded Langer, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, New York, NY
  • ,
  • Ram Kerner, MD

      Affiliations

    • Department of Obstetrics and Gynecology, St. Luke's-Roosevelt Hospital Center, New York, NY
  • ,
  • Gal Ben David, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Bnai Zion Medical Center, Haifa, Israel
  • ,
  • Ilan Calderon, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Bnai Zion Medical Center, Haifa, Israel

Received 26 February 2008 ,Revised 10 July 2008 ,Accepted 1 August 2008.

References 

  1. Mathews TJ, Menacker F, MacDorman MF. Infant mortality statistics from the 2002 period: linked birth/infant death data set. Natl Vital Stat Rep. 2004;53:1–29
  2. Garfield RE, Maner WL. Physiology and electrical activity of uterine contractions. Seminars Cell Dev Biol. 2007;18:289–295
  3. King JF, Grant A, Keirse MJNC, Chalmers I. Beta-mimetics in preterm labor: An overview of the randomized clinical trials. Br J Obstet Gynaecol. 1988;95:211–222
  4. Iams JD, Newman RB, Thom EA, et al. Frequency of uterine contractions and the risk of spontaneous preterm delivery. N Engl J Med. 2001;346:250–255
  5. American College of Obstetricians and Gynecologists. ACOG practice bulletin: Assessment of risk factors for preterm birth: clinical management guidelines for obstetrician-gynecologists. Number 31 October 2001;
  6. Lockwood CJ, Senyei AE, Dische MR, et al. Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery. N Engl J Med. 1991;325:669–674
  7. Iams JD, Casal D, McGregor J, et al. Fetal fibronectin improves the accuracy of diagnosis of preterm labor. Am J Obstet Gynecol. 1995;173:141–145
  8. Iams JD, Goldenberg RL, Meis PJ, et al. The length of the cervix and the risk of spontaneous premature delivery (National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network). N Engl J Med. 1996;334:567–572
  9. Kuriyama H, Csapo A. A study of the parturient uterus with the microelectrode technique. Endocrinology. 1961;68:1010–1025
  10. Marshall J. Regulation of activity in uterine smooth muscle. Physiol Rev. 1962;5:213–227
  11. Buhimschi C, Boyle MB, Saade GR, Garfield RE. Uterine activity during pregnancy and labor assessed by simultaneous recordings from the myometrium and abdominal surface in the rat. Am J Obstet Gynecol. 1998;178:811–822
  12. Demianczuk N, Towell ME, Garfield RE. Myometrial electrophysiologic activity and gap junctions in the pregnant rat. Am J Obstet Gynecol. 1984;149:485–491
  13. Marque C, Duchene JM, Leclercq S, Panczer GS, Chaumont J. Uterine EHG processing for obstetrical monitoring. IEEE Trans Biomed Eng. 1986;33:1182–1187
  14. Buhimschi C, Boyle MB, Garfield RE. Electrical activity of the human uterus during pregnancy as recorded from the abdominal surface. Obstet Gynecol. 1997;90:102–111
  15. Maner WL, Garfield RE, Maul H, Olson G, Saade G. Predicting preterm delivery with transabdominal uterine electromyography. Obstet Gynecol. 2003;101:1254–1260
  16. Garfield RE, Maner WL, MacKay LB, Schlembach D, Saade GR. Comparing uterine electromyography activity of antepartum patients versus term labor patients. Am J Obstet Gynecol. 2005;193:23–29
  17. Kilner JM, Baker SN, Lemon RN. A novel algorithm to remove electrical cross-talk between surface EMG recordings and its application to the measurement of short-term synchronization in humans. J Physiol. 2002;538:919–930
  18. Matsura T, Maekawa S, Kotani M. Three-dimensional position estimation of the motor unit from surface EMG signals. Presented at the 2003 Annual Conference of the Society of Instrument and Control Engineers In: Japan: Fukui; August 2003;
  19. Beck RBJ, Houtman CJ, Oapos Malley MJ, Lowery MM, Stegeman DF. A technique to track individual motor unit action potentials in surface EMG by monitoring their conduction velocities and amplitudes. IEEE Trans Biomed Eng. 2005;52:622–629
  20. Iams JD. Prediction and early detection of preterm labor. Obstet Gynecol. 2003;101:402–412
  21. Adeza Biomedical. Rapid fFN cassette, catalog number 00864. Sunnyvale (CA): Adeza Biomedical Corp; 1999;
  22. McKenna DS, Chung K, Iams JD. Effect of digital cervical examination on the expression of fetal fibronectin. J Reprod Med. 1999;44:796–800
  23. Spong C. Prediction and prevention of recurrent spontaneous preterm birth. Obstet Gynecol. 2007;110:405–415
  24. Hoesli I, Tercanli S, Holzgreve W. Cervical length assessment by ultrasound as a predictor of preterm labour—is there a role for routine screening?. BJOG. 2003;110(Suppl 20):61–65
  25. Maul H, Maner WL, Olson G, Saade GR, Garfield R. Non-invasive transabdominal uterine electromyography correlates with the strength of intrauterine pressure and is predictive of labor and delivery. J Matern Fetal Neonatal Med. 2004;15:297–301
  26. Garfield R, Maner W, Maul H, Saade G. Use of uterine EMG and cervical LIF in monitoring pregnant patients. BJOG. 2005;112(Suppl 1):103–108
  27. Shi SQ, Maner WL, Mackay LB, Garfield RE. Identification of term and preterm labor in rats using artificial neural networks on uterine electromyography signals. Am J Obstet Gynecol. 2007;198:235.e1–235.e4
  28. Maner WL, Garfield RE. Identification of human term and preterm labor using artificial neural networks on uterine electromyography data. Ann Biomed Eng. 2007;35:465–473
  29. Lammers WJEP, Arafat K, El-Kays A, El-Sharwaky TY. Spatial and temporal variations in local spike propagation in the myometrium of the 17-day pregnant rat. Am J Physiol. 1994;267:C1210–C1223
  30. Lammers W. Circulating excitations and re-entry in the pregnant uterus. Eur J Physiol. 1997;433:287–293
  31. Lammers W, Hamid R. The initiation, continuation, and termination of spontaneous episodes of circus movements in the pregnant myometrium of the rat. Am J Obstet Gynecol. 1998;179:1515–1526
  32. Lammers W, Mirghani H, Stephen B, et al. Patterns of electrical propagation in the intact pregnant guinea pig uterus. Am J Physiol Regul Integr Comp Physiol. 2007;294:R919–R928
  33. Jiang W, Li G, Lin L. Uterine electromyogram topography to represent synchronization of uterine contractions. Int J Gynecol Obstet. 2007;97:120–124
  34. Euliano T, Nguyen MT, Marossero D, Edwards R. Monitoring contractions in obese parturients. Obstet Gynecol. 2007;109:1136–1140

 Cite this article as: Most O, Langer O, Kerner R, David GB, Calderon I. Can myometrial electrical activity identify patients in preterm labor? Am J Obstet Gynecol 2008;199:378.e1-378.e6.

PII: S0002-9378(08)00911-3

doi: 10.1016/j.ajog.2008.08.003

American Journal of Obstetrics & Gynecology
Volume 199, Issue 4 , Pages 378.e1-378.e6 , October 2008