American Journal of Obstetrics & Gynecology
Volume 200, Issue 1 , Pages 46.e1-46.e5, January 2009

Maternal thrombophilia and the risk of recurrence of preeclampsia

  • Fabio Facchinetti, MD

      Affiliations

    • Mother-Infant Department, Unit of Gynecology and Obstetrics, Faculty of Medicine and Surgery, University of Modena and Reggio Emilia, Italy
    • Corresponding Author InformationReprints: Professor Fabio Facchinetti, Dipartimento Materno Infantile, Via del Pozzo 71, 41100 Modena, Italy
    • ,
  • Luca Marozio, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine and Surgery, University of Turin, Turin, Italy
    • ,
  • Tiziana Frusca, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, University of Brescia, Brescia, Italy
    • ,
  • Elvira Grandone, MD

      Affiliations

    • Atherosclerosis and Thrombosis Unit, Istituto di Ricovero e Cura a Carettere Scientifico “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo (FG), Italy
    • ,
  • Paolo Venturini, MD

      Affiliations

    • Mother-Infant Department, Unit of Gynecology and Obstetrics, Faculty of Medicine and Surgery, University of Modena and Reggio Emilia, Italy
    • ,
  • Giovanni Luca Tiscia, MD

      Affiliations

    • Atherosclerosis and Thrombosis Unit, Istituto di Ricovero e Cura a Carettere Scientifico “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo (FG), Italy
    • ,
  • Sonia Zatti, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, University of Brescia, Brescia, Italy
    • ,
  • Chiara Benedetto, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine and Surgery, University of Turin, Turin, Italy

Received 9 January 2008; received in revised form 29 April 2008; accepted 15 July 2008. published online 10 October 2008.

Objective

The aim of this prospective study was to determine the impact of thrombophilia on the recurrence of preeclampsia.

Study Design

In a multicenter, observational, cohort design, 172 white patients with a previous pregnancy complicated by preeclampsia were observed in the next pregnancy. They were evaluated for heritable thrombophilia (factor V Leiden and factor II G20210A mutations, protein S, protein C, and antithrombin deficiency), hyperhomocystinemia, lupus anticoagulant, and anticardiolipin antibodies. Development of preeclampsia and maternal complications and both gestational age at delivery and birthweight were recorded.

Results

Sixty women (34.9%) showed the presence of a thrombophilic defect. They had a higher risk for the recurrence of preeclampsia (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.2-5.1), compared to patients without thrombophilia. Similar findings were observed considering only heritable thrombophilia. Thrombophilic patients were at increased risk for the occurrence of very early preterm delivery (< 32 weeks; OR, 11.6; 95% CI, 3.4-43.2).

Conclusion

When counseling white women with a history of preeclampsia, screening for thrombophilia can be useful for preconceptional counseling and pregnancy management.

Key words: factor V Leiden, heritable thrombophilia, preeclampsia, prothrombin mutation, thrombophilia

 

 Cite this article as: Facchinetti F, Marozio L, Frusca T, et al. Maternal thrombophilia and the risk of recurrence of preeclampsia. Am J Obstet Gynecol 2009;200:46.e1-46.e5.

PII: S0002-9378(08)00815-6

doi:10.1016/j.ajog.2008.07.032

American Journal of Obstetrics & Gynecology
Volume 200, Issue 1 , Pages 46.e1-46.e5, January 2009