American Journal of Obstetrics & Gynecology
Volume 199, Issue 4 , Pages 433.e1-433.e8 , October 2008

Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis

Presented at the 28th annual meeting of the Society for Maternal–Fetal Medicine, Dallas, TX, Jan. 28-Feb. 2, 2008.

  • Joseph A. Spinnato II, MD

      Affiliations

    • University of Cincinnati College of Medicine, Cincinnati, OH
    • ,
  • Salvio Freire, MD

      Affiliations

    • Universidade Federal de Pernambuco, Hospital das Clínicas, Recife, Brazil
    • ,
  • Joao Luiz Pinto e Silva, MD

      Affiliations

    • Universidade Estadual de Campinas, Campinas, Brazil
    • ,
  • Marilza Vieira Cunha Rudge, MD

      Affiliations

    • Universidade Estadual Paulista, Botucatu, Brazil
    • ,
  • Sérgio Martins-Costa, MD

      Affiliations

    • Universidade Federal do Rio Grande do Sul, Hospital de Clínicas, Porto Alegre, Brazil
    • ,
  • Matthew A. Koch, MD, PhD

      Affiliations

    • RTI International, Research Triangle Park, NC
    • ,
  • Norman Goco, MHS

      Affiliations

    • RTI International, Research Triangle Park, NC
    • ,
  • Cleide de Barros Santos, MD

      Affiliations

    • Universidade Federal de Pernambuco, Hospital das Clínicas, Recife, Brazil
    • ,
  • Jose Guilherme Cecatti, MD

      Affiliations

    • Universidade Estadual de Campinas, Campinas, Brazil
    • ,
  • Roberto Costa, MD

      Affiliations

    • Universidade Estadual Paulista, Botucatu, Brazil
    • ,
  • José Geraldo Ramos, MD

      Affiliations

    • Universidade Federal do Rio Grande do Sul, Hospital de Clínicas, Porto Alegre, Brazil
    • ,
  • Nancy Moss, PhD

      Affiliations

    • National Institute of Child Health and Human Development, Bethesda, MD
    • ,
  • Baha M. Sibai, MD

      Affiliations

    • University of Cincinnati College of Medicine, Cincinnati, OH

Received 28 February 2008 ,Revised 16 April 2008 ,Accepted 7 July 2008.

References 

  1. Premature rupture of the membranes (ACOG Practice Bulletin). 2007;Number 80. April
  2. Woods JR, Plessinger MA, Miller RK. Vitamins C and E: missing links in preventing preterm premature rupture of membranes?. Am J Obstet Gynecol. 2001;185:5–10
  3. Woods JR. Reactive oxygen species and preterm premature rupture of membranes-a review. Placenta. 2001;22(Suppl A):S38–S44
  4. Spinnato JA, Freire S, Pinto e Silva JL, et al. Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Obstet Gynecol. 2007;110:1311–1318
  5. Alexander GR, Himes JH, Kaufman RB, Mor J, Kogan M. A United States national reference for fetal growth. Obstet Gynecol. 1996;87:163–168
  6. DeMets DL, Lan KKG. Interim analysis: the alpha spending function approach. Stat Med. 1994;13:1341–1352discussion 1353-6
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  8. Hosmer DW, Lemeshow S. Applied logistic regression. 2nd ed.. New York: John Wiley & Sons, Inc; 2000;
  9. Barrett BM, Sowell A, Gunter E, Wang M. Potential role of ascorbic acid and beta-carotene in the prevention of preterm rupture of fetal membranes. Int J Vitam Nutr Res. 1994;64:192–197
  10. Plessinger MA, Woods JR, Miller RK. Pretreatment of human amnion-chorion with vitamins C and E prevents hypochlorous acid-induced damage. Am J Obstet Gynecol. 2000;183:979–985
  11. Wall PD, Pressman EK, Woods JR. Preterm premature rupture of the membranes and antioxidants: the free radical connection. J Perinat Med. 2002;30:447–457
  12. Siega-Riz AM, Promislow JH, Savitz DA, Thorp JM, McDonald T. Vitamin C intake and the risk of preterm delivery. Am J Obstet Gynecol. 2003;189:519–525
  13. Casanueva E, Ripoll C, Tolentino M, et al. Vitamin C supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial. Am J Clin Nutr. 2005;81:859–863
  14. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet. 1999;354:810–816
  15. Beazley D, Ahokas R, Livingston J, et al. Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2005;192:520–521
  16. Rumbold AR, Crowther CA, Haslam RR, et al. ACTS Study Group Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med. 2006;354:1796–1806
  17. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamins in Pre-eclampsia (VIP) Trial Consortium (Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial). Lancet. 2006;367:1145–1154
  18. Kilsztajn S, Carmo MS, Machado LC, Lopes ES, Lima LZ. Caesarean sections and maternal mortality in Sao Paulo. Eur J Obstet Gynecol Reprod Biol. 2007;132:64–69

 Cite this article as: Spinnato JA II, Freire S, Pinto e Silva JL, et al. Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis. Am J Obstet Gynecol 2008;199:433.e1-433.e8.

 Reprints not available from the authors.

 This effort was supported by Grant Number 1 U01 HD40565 cosponsored by the National Institute of Child Health and Human Development and the Bill and Melinda Gates Foundation.

 ClinicalTrials.gov Identifier: NCT00097110.

PII: S0002-9378(08)00800-4

doi: 10.1016/j.ajog.2008.07.011

American Journal of Obstetrics & Gynecology
Volume 199, Issue 4 , Pages 433.e1-433.e8 , October 2008

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