American Journal of Obstetrics & Gynecology
Volume 199, Issue 4 , Pages 387.e1-387.e4 , October 2008

Severe fetal thrombocytopenia in Rhesus D alloimmunized pregnancies

Presented at the 28th Annual Meeting of the Society for Maternal-Fetal Medicine, Dallas, TX, Jan. 30-Feb. 2, 2008.

  • Eline S.A. van den Akker, MD, PhD

      Affiliations

    • Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands
    • Corresponding Author InformationReprints: E. S. A. van den Akker, MD, PhD, Leiden University Medical Center, Department of Obstetrics, K6-31, PO Box 9600, 2300 RC Leiden, The Netherlands
    • ,
  • Timo R. de Haan, MD, PhD

      Affiliations

    • Division of Neonatology, Department of Pediatrics, Academic Medical Center, Amsterdam, the Netherlands
    • ,
  • Enrico Lopriore, MD, PhD

      Affiliations

    • Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands
    • ,
  • Anneke Brand, MD, PhD

      Affiliations

    • Department of Immunohematology, Leiden University Medical Center, Leiden, the Netherlands
    • Sanquin Blood Bank Southwest Region, Rotterdam, the Netherlands
    • ,
  • Humphrey H.H. Kanhai, MD, PhD

      Affiliations

    • Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands
    • ,
  • Dick Oepkes, MD, PhD

      Affiliations

    • Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands

Received 8 January 2008 ,Revised 18 June 2008 ,Accepted 2 July 2008.

References 

  1. Van den Hof MC, Nicolaides KH. Platelet count in normal, small, and anemic fetuses. Am J Obstet Gynecol. 1990;162:735–739
  2. Segal M, Manning FA, Harman CR, Menticoglou S. Bleeding after intravascular transfusion: Experimental and clinical observations. Am J Obstet Gynecol. 1991;165:1414–1418
  3. Saade GR, Moise KJ, Copel JA, Belfort MA, Carpenter RJ. Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization. Obstet Gynecol. 1993;82:987–991
  4. Hohlfeld P, Forestier F, Kaplan C, Tissot JD, Daffos F. Fetal thrombocytopenia: A retrospective survey of 5,194 fetal blood samplings. Blood. 1994;84:1851–1856
  5. Jhawar BS, Ranger A, Steven D, Del Maestro RF. Risk factors for intracranial hemorrhage among full-term infants: A case-control study. Neurosurgery. 2003;52:581–590
  6. Van den Akker ESA, Klumper FJCM, Brand A, Kanhai HHH, Oepkes D. Kell alloantibodies in pregnancy do not cause fetal thrombocytopenia. Vox Sang. 2008;95:66–69
  7. Van Kamp IL, Klumper FJCM, Meerman RH, Oepkes D, Scherjon SA, Kanhai HHH. Treatment of fetal anaemia due to red-cell alloimmunization with intrauterine transfusions in the Netherlands, 1988-1999. Acta Obstet Gynecol Scand. 2004;83:731–737
  8. Van Kamp IL, Klumper FJCM, Bakkum RSLA, et al. The severity of immune fetal hydrops is predictive of fetal outcome after intrauterine treatment. Am J Obstet Gynecol. 2001;185:668–673
  9. Van Kamp IL, Klumper FJ, Oepkes D, et al. Complications of intrauterine intravascular transfusions for fetal anemia due to maternal red cell alloimmunization. Am J Obstet Gynecol. 2005;192:171–177
  10. Overton TG, Duncan KR, Jolly M, Letsky E, Fisk NM. Serial aggressive platelet transfusion for fetal alloimmune thrombocytopenia: Platelet dynamics and perinatal outcome. Am J Obstet Gynecol. 2002;186:826–831
  11. Berkowitz RL, Kolb EA, McFarland JG, et al. Parallel randomized trials of risk-based therapy for fetal alloimmune thrombocytopenia. Obstet Gynecol. 2006;07:91–96

 Cite this article as: van den Akker ESA, de Haan TR, Lopriore E, et al. Severe fetal thrombocytopenia in Rhesus D alloimmunized pregnancies. Am J Obstet Gynecol 2008;199:387.e1-387.e4.

PII: S0002-9378(08)00785-0

doi: 10.1016/j.ajog.2008.07.001

American Journal of Obstetrics & Gynecology
Volume 199, Issue 4 , Pages 387.e1-387.e4 , October 2008

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