American Journal of Obstetrics & Gynecology
Volume 200, Issue 1 , Pages 63.e1-63.e5 , January 2009

Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study

  • Ronit Calderon-Margalit, MD, MPH

      Affiliations

    • Hebrew University–Hadassah Braun School of Public Health, Jerusalem, Israel
    • Corresponding Author InformationReprints: Ronit Calderon-Margalit, MD, MPH, Hebrew University-Hadassah Braun School of Public Health, POB 12272, 91120 Jerusalem, Israel
    • ,
  • Yechiel Friedlander, PhD

      Affiliations

    • Hebrew University–Hadassah Braun School of Public Health, Jerusalem, Israel
    • ,
  • Rivka Yanetz, PhD

      Affiliations

    • Hebrew University–Hadassah Braun School of Public Health, Jerusalem, Israel
    • ,
  • Lisa Deutsch, PhD

      Affiliations

    • Hebrew University–Hadassah Braun School of Public Health, Jerusalem, Israel
    • ,
  • Mary C. Perrin, DrPH

      Affiliations

    • Department of Psychiatry, New York University School of Medicine, New York, NY
    • ,
  • Karine Kleinhaus, MD, MPH

      Affiliations

    • Department of Psychiatry, Columbia University, New York, NY
    • ,
  • Efrat Tiram, MSc

      Affiliations

    • Hebrew University–Hadassah Braun School of Public Health, Jerusalem, Israel
    • ,
  • Susan Harlap, MBBS

      Affiliations

    • Department of Psychiatry, New York University School of Medicine, New York, NY
    • Department of Epidemiology, Columbia University, New York, NY
    • ,
  • Ora Paltiel, MDCM, MSc, FRCPC

      Affiliations

    • Hebrew University–Hadassah Braun School of Public Health, Jerusalem, Israel

Received 8 January 2008 ,Accepted 19 June 2008.

References 

  1. Terry MB, Perrin M, Salafia CM, et al. Preeclampsia, pregnancy-related hypertension, and breast cancer risk. Am J Epidemiol. 2007;165:1007–1014
  2. Innes KE, Byers TE. First pregnancy characteristics and subsequent breast cancer risk among young women. Int J Cancer. 2004;112:306–311
  3. Polednak AP, Janerich DT. Characteristics of first pregnancy in relation to early breast cancer: a case-control study. J Reprod Med. 1983;28:314–318
  4. Troisi R, Weiss HA, Hoover RN, et al. Pregnancy characteristics and maternal risk of breast cancer. Epidemiology. 1998;9:641–647
  5. Vatten LJ, Romundstad PR, Trichopoulos D, Skjaerven R. Pre-eclampsia in pregnancy and subsequent risk for breast cancer. Br J Cancer. 2002;87:971–973
  6. Troisi R, Innes KE, Roberts JM, Hoover RN. Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role?. Br J Cancer. 2007;97:688–690
  7. Vatten LJ, Forman MR, Nilsen TI, Barrett JC, Romundstad PR. The negative association between pre-eclampsia and breast cancer risk may depend on the offspring's gender. Br J Cancer. 2007;96:1436–1438
  8. Irgens HU, Reisaeter L, Irgens LM, Lie RT. Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. BMJ. 2001;323:1213–1217
  9. Aagaard-Tillery KM, Stoddard GJ, Holmgren C, et al. Preeclampsia and subsequent risk of cancer in Utah. Am J Obstet Gynecol. 2006;195:691–699
  10. Paltiel O, Friedlander Y, Tiram E, Barchana M, Xue X, Harlap S. Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort. BMJ. 2004;328:919
  11. Harlap S, Davies AM, Deutsch L, et al. The Jerusalem Perinatal Study cohort, 1964-2005: methods and a review of the main results. Paediatr Perinat Epidemiol. 2007;21:256–273
  12. Richardson BE, Peck JD, Wormuth JK. Mean arterial pressure, pregnancy-induced hypertension, and preeclampsia: evaluation as independent risk factors and as surrogates for high maternal serum alpha-fetoprotein in estimating breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2000;9:1349–1355
  13. Lynch HT, Rubinstein WS, Locker GY. Cancer in Jews: introduction and overview. Fam Cancer. 2004;3:177–192
  14. Israel Cancer Registry, Ministry of Health. Cancer incidence in Israel by age and country of birth, 2001 - breast and ovary. Available at: http://heath.gov.il/download/sartan/2001/Breast2.xls and http://www.heath.gov.il/download/sartan/2001/ovary2.xls. Accessed July 28, 2008.
  15. King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science. 2003;302:643–646
  16. Calderon-Margalit R, Paltiel O. Prevention of breast cancer in women who carry BRCA1 or BRCA2 mutations: a critical review of the literature. Int J Cancer. 2004;112:357–364
  17. Weiss-Salz I, Harlap S, Friedlander Y, et al. Ethnic ancestry and increased paternal age are risk factors for breast cancer before the age of 40 years. Eur J Cancer Prev. 2007;16:549–554

 This study was supported by the National Institutes of Health Grant R01 CA080197.

 Cite this article as: Calderon-Margalit R, Friedlander Y, Yanetz R, et al. Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study. Am J Obstet Gynecol 2009;200:63.e1-63.e5.

PII: S0002-9378(08)00689-3

doi: 10.1016/j.ajog.2008.06.057

American Journal of Obstetrics & Gynecology
Volume 200, Issue 1 , Pages 63.e1-63.e5 , January 2009

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