Volume 200, Issue 1 , Pages 63.e1-63.e5, January 2009
Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study
Objective
The purpose of this study was to examine the association between preeclampsia and cancer incidence.
Study Design
The Jerusalem Perinatal Study is a population-based cohort of all births to 41,206 residents of Western Jerusalem from 1964-76. Cancer incidence to 2004 was assessed by linkage of the cohort with the Israel Cancer Registry. Cox's proportional hazards models were constructed to estimate the hazard ratio for cancer among women who had had preeclampsia.
Results
Preeclampsia was associated with a 1.23-fold increased risk of cancer at all sites, a 37% increased risk of breast cancer, and more than a doubling of ovarian cancer risk. Analysis by morphologic condition yielded significantly increased risks for malignancies that were classed as cystic mucinous and serous (relative risk, 1.96; 95% CI, 1.00-3.83) and for ductal, lobular, and medullary carcinomas (relative risk, 1.40; 95% CI, 1.07-1.83). No differential association was observed by sex of offspring.
Conclusion
Our study suggests that the previously described protective effect of preeclampsia on cancer is not universal.
Key words: cancer, cohort, morphologic condition, preeclampsia, risk, sex
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This study was supported by the National Institutes of Health Grant R01 CA080197.
Cite this article as: Calderon-Margalit R, Friedlander Y, Yanetz R, et al. Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study. Am J Obstet Gynecol 2009;200:63.e1-63.e5.
PII: S0002-9378(08)00689-3
doi:10.1016/j.ajog.2008.06.057
© 2009 Mosby, Inc. All rights reserved.
Volume 200, Issue 1 , Pages 63.e1-63.e5, January 2009
