American Journal of Obstetrics & Gynecology
Volume 199, Issue 4 , Pages 429.e1-429.e6 , October 2008

Atrial natriuretic peptide production and natriuretic peptide receptors in the human uterus and their effect on myometrial relaxation

Presented at the 28th Annual Meeting of the Society for Maternal-Fetal Medicine, Dallas, TX, Jan. 28-Feb. 2, 2008.

  • Alice C. Cootauco, MD

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD
    • Corresponding Author InformationReprints: Alice Cootauco, MD, 600 North Wolfe St, Phipps 214, Baltimore, MD 21287
    • ,
  • Jamie D. Murphy, MD

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD
    • ,
  • Jerome Maleski

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD
    • ,
  • Karin J. Blakemore, MD

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD
    • ,
  • Martin K. Slodzinski, MD, PhD

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD

Received 11 March 2008 ,Revised 3 April 2008 ,Accepted 24 May 2008.

References 

  1. de Bold AJ. Heart atria granularity effects of changes in water-electrolyte balance. Proc Soc Exp Biol Med. 1979;161:508–511
  2. de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981;28:89–94
  3. Sudoh T, Minamino N, Kangawa K, Matsuo H. A new natriuretic peptide in porcine brain. Nature. 1988;332:78–81
  4. Minamino N, Aburaya M, Ueda S, Kangawa K, Matsuo H. The presence of brain natriuretic peptide of 12,000 daltons in porcine heart. Biochem Biophys Res Commun. 1988;155:740–746
  5. Zeidel ML. Hormonal regulation of inner medullary collecting duct sodium transport. Am J Physiol. 1993;265:F159–F173
  6. Atarashi K, Mulrow PJ, Franco-Saenz R. Effect of atrial peptides on aldosterone production. J Clin Invest. 1985;76:1807–1811
  7. Burnett JC, Granger JP, Opgenorth TJ. Effects of synthetic atrial natriuretic factor on renal function and renin release. Am J Physiol. 1984;247:F863–F868
  8. Genest J, Cantin M. The atrial natriuretic factor: its physiology and biochemistry. Rev Physiol Biochem Pharmacol. 1989;110:1–145
  9. Maack T. The broad homeostatic role of natriuretic peptides. Arq Bras Endocrinol Metab. 2006;50:198–207
  10. Russinova A, Mourdjeva M, Valkova C, Kyurkchiev S, Kehayov I. Immunocytochemical localization of atrial natriuretic factor (ANF) in rat female reproductive tract: evidence for a potential hormonal regulation. Biol Cell. 2002;94:91–98
  11. Dos Reis AM, Fujio N, Mukaddam-Daher S, Jankowski M, Tremblay J, Gutkowska J. Characterization and distribution of natriuretic peptide receptors in the rat uterus. Endocrinology. 1995;136:4247–4253
  12. Itoh H, Sagawa N, Hasegawa M, et al. Expression of biologically active receptors for natriuretic peptides in the human uterus during pregnancy. Biochem Biophys Res Commun. 1994;203:602–607
  13. Suga S, Nakao K, Hosoda S, et al. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology. 1992;130:229–239
  14. Graham CH, Watson JD, Blumenfeld AJ, Pang SC. Expression of atrial natriuretic peptide by third-trimester placental cytotrophoblasts in women. Biol Reprod. 1996;54:834–840
  15. Anand-Srivastava MB, Sairam MR, Cantin M. Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. J Biol Chem. 1990;265:8566–8572
  16. Potvin W, Varma DR. Down regulation of myometrial atrial natriuretic factor receptors by progesterone and pregnancy and upregulation by oestrogen in rats. J Endocrinol. 1991;131:259–266
  17. Potvin W, Varma DR. Refractoriness of the gravid rat uterus to tocolytic and biochemical effects of atrial natriuretic peptide. Br J Pharmacol. 1990;100:341–347
  18. Buhimschi IA, San Martin-Clark O, Aguan K, Thompson LP, Weiner CP. Differential alterations in responsiveness in particulate and soluble guanylate cyclases in pregnant guinea pig myometrium. Am J Obstet Gynecol. 2000;183:1512–1519
  19. Carvajal JA, Aguan K, Thompson LP, Buhimschi IA, Weiner CP. Natriuretic peptide-induced relaxation of myometrium from the pregnant guinea pig is not mediated by guanylate cyclase activation. J Pharmacol Exp Ther. 2001;297:181–188
  20. Telfer JF, Itoh H, Thomson A, et al. Activity and expression of soluble and particulate guanylate cylase in myometrium from nonpregnant and pregnant women: down-regulation of soluble guanylate cyclase at term. J Clin Endocrinol Metab. 2001;86:5934–5943
  21. Itoh H, Sagawa N, Hasegawa M, et al. Brain natriuretic peptide is present in the human amniotic fluid and is secreted from amniotic cells. J Clin Endocrinol Metab. 1993;74:907–911
  22. Yoshimura T, Yoshimura M, Yasue H, et al. Plasma concentration of atrial natriuretic peptide and brain natriuretic peptide during normal human pregnancy and the postpartum period. J Endocrinol. 1994;140:393–397
  23. Yoshizumi M, Houchi H, Tsuchiya K, et al. Atrial natriuretic peptide stimulates Na+-dependent Ca2+ efflux from freshly isolated adult rat cardiomyocytes. FEBS Lett. 1997;419:255–258

 Cite this article as: Cootauco AC, Murphy JD, Maleski J, et al. Atrial natriuretic peptide production and natriuretic peptide receptors in the human uterus and effect on myometrial relaxation. Am J Obstet Gynecol 2008;199:429.e1-429.e6.

PII: S0002-9378(08)00562-0

doi: 10.1016/j.ajog.2008.05.019

American Journal of Obstetrics & Gynecology
Volume 199, Issue 4 , Pages 429.e1-429.e6 , October 2008

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