American Journal of Obstetrics & Gynecology
Volume 199, Issue 2 , Pages 125.e1-125.e5 , August 2008

Morbidity associated with sickle cell disease in pregnancy

This study was presented at the 27th Annual Clinical Meeting of the Society for Maternal-Fetal Medicine, San Francisco, CA, Feb. 5-10, 2007.

  • Margaret S. Villers, MD

      Affiliations

    • Division of Gynecology and General Obstetrics, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC
    • ,
  • Margaret G. Jamison, PhD

      Affiliations

    • School of Medicine, University of North Carolina, Chapel Hill, NC
    • ,
  • Laura M. De Castro, MD

      Affiliations

    • Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC
    • ,
  • Andra H. James, MD, MPH

      Affiliations

    • Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC.
    • Corresponding Author InformationReprints: Andra H. James, MD, Duke University Medical Center, Box 3967, Durham, NC 27710.

Received 18 October 2007 ,Accepted 8 April 2008.

References 

  1. Samuels P. Hematologic complications of pregnancy. In:  Gabbe SG,  Niebyl JA,  Simpson JL editor. Obstetrics: normal and problem pregnancies. 4th ed.. Philadelphia: Churchill Livingstone; 2002;p. 1169–1193
  2. Hassell K. Pregnancy and sickle cell disease. Hematol Oncol Clin North Am. 2005;19:903–916
  3. American College of Obstetrics and Gynecology Committee on Obstetrics. Hemoglobinopathies in pregnancy: practice bulletin no.: 78. Obstet Gynecol. 2007;109:229–237
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  9. Overview of the Nationwide Inpatient Sample (NIS) 2000. In: Healthcare Cost and Utilization Project (HCUP) sponsored by the Agency for Healthcare Research and Quality. Rockville (MD): Agency for Healthcare Research and Quality; 2002;p. 1–24
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  11. Stein PD, Beemath A, Meyers FA, Skaf E, Olson RE. Deep vein thrombosis and pulmonary embolism in hospitalized patient with sickle cell disease. Am J Med. 2006;119:897e.7–897e.11
  12. James AH, Jamison MG, Brancazio LR, Myers ER. Venous thromboembolism during pregnancy and the postpartum period. Am J Obstet Gynecol. 2006;194:1311–1315
  13. Ataga KI, Sood N, De Gent G, et al. Pulmonary hypertension in sickle cell disease. Am J Med. 2004;117:665–669
  14. Seoud MA, Cantwell C, Nobles G, Levy DL. Outcome of pregnancies complicated by sickle cell and sickle-C hemoglobinopathies. Am J Perinatol. 1994;11:187–191
  15. Yasmeen S, Romano PS, Schembri ME, Keyzer JM, Gilbert WM. Accuracy of obstetric diagnoses and procedures in hospital discharge data. Am J Obstet Gynecol. 2006;194:992–1001
  16. Koshy M, Burd L, Wallace D, Moawad A, Baron J. Prophylactic red-cell transfusions in pregnant patients with sickle cell disease: a randomized cooperative study. N Engl J Med. 1988;319:1447–1452

 Cite this article as: Villers MS, Jamison MG, De Castro LM, James AH. Morbidity associated with sickle cell disease in pregnancy. Am J Obstet Gynecol 2008;199:125.e1-125.e5.

 This study was funded in part by grant 5K12-D043446-03 from the National Institutes of Health.

PII: S0002-9378(08)00407-9

doi: 10.1016/j.ajog.2008.04.016

American Journal of Obstetrics & Gynecology
Volume 199, Issue 2 , Pages 125.e1-125.e5 , August 2008

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