American Journal of Obstetrics & Gynecology
Volume 199, Issue 1 , Pages 32.e1-32.e5 , July 2008

Higher maximum doses of oxytocin are associated with an unacceptably high risk for uterine rupture in patients attempting vaginal birth after cesarean delivery

Presented at the 28th Annual Meeting of the Society for Maternal-Fetal Medicine, Dallas, TX, Jan. 28 to Feb. 2, 2008.

  • Alison G. Cahill, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO
    • ,
  • Brian M. Waterman, MPH

      Affiliations

    • Department of Medicine, Washington University School of Medicine, St. Louis, MO.
    • ,
  • David M. Stamilio, MD, MSCE

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO
    • ,
  • Anthony O. Odibo, MD, MSCE

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO
    • ,
  • Jenifer E. Allsworth, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO
    • ,
  • Bradley Evanoff, MD, MPH

      Affiliations

    • Department of Medicine, Washington University School of Medicine, St. Louis, MO.
    • ,
  • George A. Macones, MD, MSCE

      Affiliations

    • Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO

Received 26 September 2007 ,Revised 18 December 2007 ,Accepted 3 March 2008.

References 

  1. Macones GA, Peipert J, Nelson DB, et al. Maternal complications with vaginal birth after cesarean delivery: A multicenter study. Am J Obstet Gynecol. 2005;193:1656–1662
  2. Landon MB, Hauth JC, Leveno KJ, et al. Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery. N Engl J Med. 2004;351:2581–2589
  3. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S. Births: Final data for 2004. Natl Vital Stat Rep. 2006;55:1–101
  4. Goetzl L, Shipp TD, Cohen A, Zelop CM, Repke JT, Lieberman E. Oxytocin dose and the risk of uterine rupture in trial of labor after cesarean. Obstet Gynecol. 2001;97:381–384
  5. Grambsch PM. Goodness-of-fit and diagnostics for proportional hazards regression models. Cancer Treat Res. 1995;75:95–112
  6. Zelop CM, Shipp TD, Repke JT, Cohen A, Caughey AB, Lieberman E. Uterine rupture during induced or augmented labor in gravid women with one prior cesarean delivery. Am J Obstet Gynecol. 1999;181:882–886
  7. Ravasia DJ, Wood SL, Pollard JK. Uterine rupture during induced trial of labor among women with previous cesarean delivery. Am J Obstet Gynecol. 2000;183:1176–1179
  8. Lin C, Raynor BD. Risk of uterine rupture in labor induction of patients with prior cesarean section: an inner city hospital experience. Am J Obstet Gynecol. 2004;190:1476–1478
  9. Landon MB, Leindecker S, Spong CY, et al. The MFMU Cesarean Registry: Factors affecting the success of trial of labor after previous cesarean delivery. Am J Obstet Gynecol. 2005;193:1016–1023
  10. Cahill AG, Stamilio DM, Odibo AO, Peipert JF, Stevens EJ, Macones GA. Does a maximum dose of oxytocin affect risk for uterine rupture in candidates for vaginal birth after cesarean delivery?. Am J Obstet Gynecol. 2007;197:495;e1-5

 Cite this article as: Cahill AG, Waterman BM, Stamilio DM, et al. Higher maximum doses of oxytocin are associated with an unacceptably high risk for uterine rupture in patients attempting vaginal birth after cesarean delivery. Am J Obstet Gynecol 2008;199:32.e1-32.e5.

 Reprints not available from the authors.

 This work was supported by Grants R01 HD 35631 and K24 HD01289, both from the National Institute of Child Health and Human Development (to G.A.M.).

PII: S0002-9378(08)00262-7

doi: 10.1016/j.ajog.2008.03.001

American Journal of Obstetrics & Gynecology
Volume 199, Issue 1 , Pages 32.e1-32.e5 , July 2008

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