American Journal of Obstetrics & Gynecology
Volume 199, Issue 2 , Pages 113.e1-113.e5 , August 2008

Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study

  • Silke Schockaert, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    • ,
  • Willy Poppe, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    • ,
  • Marc Arbyn, MD

      Affiliations

    • Scientific Institute of Public Health, Brussels, Belgium, and the European Cancer Network, Lyon, France
    • ,
  • Tom Verguts, PhD

      Affiliations

    • Department of Experimental Psychology, Ghent University, Ghent, Belgium.
    • ,
  • Jasper Verguts, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium
    • Corresponding Author InformationReprints: Jasper Verguts, MD, Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.

Received 11 September 2007 ,Revised 14 November 2007 ,Accepted 12 February 2008.

References 

  1. Bray F, Loos AH, McCarron P, et al. Trends in cervical squamous cell carcinoma incidence in 13 European countries: changing risk and the effects of screening. Cancer Epidemiol Biomarkers Prev. 2005;14:677–686
  2. Arbyn M, Raifu AO, Autier P, Ferlay J. Burden of cervical cancer in Europe: Estimates for 2004. Ann Oncol. 2007;18:1708–1715
  3. Wright TC, Cox JT, Massad LS, et al. 2001 consensus guidelines for the management of women with cervical intraepithelial neoplasia. Am J Obstet Gynecol. 2003;189:295–304
  4. Martin-Hirsch PL, Paraskevaidis E, Kitchener H. Surgery for cervical intraepithelial neoplasia. Cochrane Database Syst Rev. 1999;CD001318
  5. Arbyn M, Paraskevaidis E, Martin-Hirsch P, et al. Clinical utility of HPV DNA detection: Triage of minor cervical lesions, follow-up of women treated for high-grade CIN (An update of pooled evidence). Gynecol Oncol. 2005;99(Suppl 3):7–11
  6. Soutter WP, de Barros Lopes A, Fletcher A, et al. Invasive cervical cancer after conservative therapy for cervical intraepithelial neoplasia. Lancet. 1997;349:978–980
  7. Kalliala I, Anttila A, Pukkala E, et al. Risk of cervical and other cancers after treatment of cervical intraepithelial neoplasia: Retrospective cohort study. BMJ. 2005;331:1183–1185
  8. Arbyn M, Sasieni P, Meijer CJ, Clavel C, Koliopoulos G, Dillner J. Chapter 9: Clinical applications of HPV testing: A summary of meta-analyses. Vaccine. 2006;24(Suppl 3):78–89
  9. Gadducci A, Sartori E, Maggino T, et al. The clinical outcome of patients with stage Ia1 and Ia2 squamous cell carcinoma of the uterine cervix: A Cooperation Task Force (CTF) study. Eur J Gynaecol Oncol. 2003;24:513–516
  10. Ostor AG. Studies on 200 cases of early squamous cell carcinoma of the cervix. Int J Gynecol Pathol. 1993;12:193–207
  11. Itsukaichi M, Kurata H, Matsushita M, et al. Stage Ia1 cervical squamous cell carcinoma: Conservative management after laser conisation with positive margins. Gynecol Oncol. 2003;90:387–389
  12. Van Trappen P, Gyselman V, Lowe DG, et al. Molecular quantification and mapping of lymph-node micrometastases in cervical cancer. Lancet. 2001;357:15–20
  13. Jordan J, Martin-Hirsch P, Arbyn M, et al. Chapter 6: Management of abnormal cervical cytology. In:  Arbyn M,  Anttila A,  Jordan J,  Ronco G,  Schenck U,  Segnan N,  Wiener H editor. European guidelines for quality assurance in cervical cancer screening. 2nd ed.. Luxembourg: Office for Official Publications of the European Communities; 2007;European Commission
  14. Kang SB, Roh JW, Kim JW, et al. A comparison of the therapeutic efficacies of large loop excision of the transformation zone and hysterectomy for the treatment of cervical intraepithelial neoplasia III. Int J Gynecol Cancer. 2001;11:387–391
  15. Mouithys P, Papadopoulos C, Allier G, et al. Faut-il poursuivre les frottis de dépistage après hystérectomie?. Gynecol Obstet Fertil. 2003;31:620–623
  16. Spuhler S, De Grandi P. Hystérectomie et néoplasie intra-épitheliale du tractus génital inférieur féminin. J Gynecol Obstet Reprod. 1992;21:903–907
  17. Rodolakis A, Diakomanolis E, Haidopoulos D, et al. How to avoid suboptimal management of cervical carcinoma by simple hysterectomy. Eur J Gynaecol Oncol. 1999;20:418–422
  18. Ireland D, Monaghan JM. The management of the patient with abnormal vaginal cytology following hysterectomy. Br J Obstet Gynecol. 1988;95:973–975
  19. Gallup DG, Morley GW. Carcinoma in situ of the vagina (A study and review). Obstet Gynecol. 1975;46:334–340
  20. Gemmel J, Holmes DM, Duncan ID. How frequently need vaginal smears be taken after hysterectomy for cervical intraepithelial neoplasia?. Br J Obstet Gynaecol. 1990;97:58–61
  21. Wiener JJ, Sweetnam PM, Jones JM. Long term follow-up of women after hysterectomy with a history of pre-invasive cancer of the cervix. Br J Obstet Gynaecol. 1992;99:907–910
  22. Kalogirou D, Antoniou G, Karakitsos P, et al. Vaginal intraepithelial neoplasia in patients treated for carcinoma in situ of the cervix. Eur J Gynaecol Oncol. 1997;18:188–191
  23. Babarinsa I, Mathew J, Wilson C, Oladipo A. Outcome of vaginal intraepithelial neoplasia following hysterectomy for cervical intraepithelial neoplasia. J Obstet Gynaecol. 2006;26:157–158
  24. Stokes-Lampard H, Wilson S, Waddell C, et al. Vaginal vault smears after hysterectomy for reasons other than malignancy: a systematic review of literature. BJOG. 2006;113:1354–1365
  25. Verguts J, Bronselaer B, Donders G, et al. Prediction of recurrence after treatment for high-grade cervical intraepithelial neoplasia: The role of human papillomavirus testing and age at conisation. BJOG. 2006;113:1303–1307

 Cite this article as: Schockaert S, Poppe W, Arbyn M, et al. Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study. Am J Obstet Gynecol 2008;199:113.e1-113.e5.

PII: S0002-9378(08)00172-5

doi: 10.1016/j.ajog.2008.02.026

American Journal of Obstetrics & Gynecology
Volume 199, Issue 2 , Pages 113.e1-113.e5 , August 2008

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