American Journal of Obstetrics & Gynecology
Volume 199, Issue 2 , Pages 117.e1-117.e6 , August 2008

Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cells

Presented at the 54th Annual Scientific Meeting of the Society for Gynecologic Investigation, Reno, NV, March 14-17, 2007.

  • Essam-Eldin R. Othman, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX
    • Department of Obstetrics and Gynecology, Assiut University, Assiut City, Egypt
    • ,
  • Zeng B. Zhu, MD

      Affiliations

    • Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • David T. Curiel, MD, PhD

      Affiliations

    • Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL
    • ,
  • Nilufar Khatoon, MSc

      Affiliations

    • Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX
    • ,
  • Hosam T. Salem, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Assiut University, Assiut City, Egypt
    • ,
  • Essam Al-Din M. Khalifa, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Assiut University, Assiut City, Egypt
    • ,
  • Ayman Al-Hendy, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Center for Women's Health Research, Meharry Medical School, Nashville, TN.
    • Corresponding Author InformationReprint requests: Ayman Al-Hendy, MD, PhD, Department of Obstetrics and Gynecology, Center for Women Health Research, Meharry Medical College, 1005 Dr D.B. Todd Jr Blvd, Nashville, TN 37208

Received 30 July 2007 ,Accepted 29 January 2008.

References 

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  12. Othman E, Curiel D, Al-Hendy A. Towards gene therapy of endometriosis: targeting adenovirus to human endometriotic cells using tissue-specific promoters and fiber-modified virus. Reprod Sci. 2007;14:70A;[abstract]
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  17. Breidenbach M, Rein DT, Schondorf T, et al. A new targeting approach for breast cancer gene therapy using the heparanase promoter. Cancer Lett. 2006;240:114–122
  18. Barker SD, Coolidge CJ, Kanerva A, et al. The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy. J Gene Med. 2003;5:300–310
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  21. Jingting C, Yangde Z, Yi Z, et al. Expression of heparanase and angiopoietin-2 in patients with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2008;136:199–209
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 Cite this article as: Othman ER, Zhu ZB, Curiel DT, et al. Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cells. Am J Obstet Gynecol 2008;199:117.e1-117.e6.

 Supported by Grants DOD W81XWH-05-1-0035 and NIH R01CA083821 (D.T.C.); G12 RR03032 from the National Center for Research Resources, NIH (A.A.); and a grant from the Egyptian Mission Department (E.R.O.).

PII: S0002-9378(08)00131-2

doi: 10.1016/j.ajog.2008.01.059

American Journal of Obstetrics & Gynecology
Volume 199, Issue 2 , Pages 117.e1-117.e6 , August 2008

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