American Journal of Obstetrics & Gynecology
Volume 199, Issue 1 , Pages 41.e1-41.e8 , July 2008

Neurodevelopmental outcome of premature infants after exposure to antenatal indomethacin

Presented at the Annual Meeting of the Pediatric Academic Societies, San Francisco, CA, April 29-May 2, 2006.

  • Sanjiv B. Amin, MD

      Affiliations

    • Department of Pediatrics, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, NY
    • Corresponding Author InformationReprints: Sanjiv B Amin, MD, PO Box 651, Department of Pediatrics, 601 Elmwood Avenue, Rochester, NY 14642.
    • ,
  • Majeeda Kamaluddeen, MD

      Affiliations

    • Department of Pediatrics, University of Maryland Medical Center, Baltimore, MD.
    • ,
  • Madhavi Sangem, MD

      Affiliations

    • Department of Pediatrics, University of Maryland Medical Center, Baltimore, MD.

Received 25 April 2007 ,Revised 27 September 2007 ,Accepted 31 December 2007.

References 

  1. Zuckerman H, Reiss U, Rubinstein I. Inhibition of human premature labor by indomethacin. Obstet Gynecol. 1974;44(6):787–792
  2. Niebyl JR, Blake DA, White RD, Kumor KM, Dubin NH, Robinson JC, et al. The inhibition of premature labor with indomethacin. Am J Obstet Gynecol. 1980;136(8):1014–1019
  3. Roberts D, Dalziel S. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2006;3:CD004454
  4. Lee BH, Stoll BJ, McDonald SA, Higgins RD. Adverse neonatal outcomes associated with antenatal dexamethasone versus antenatal betamethasone. Pediatrics. 2006;117(5):1503–1510
  5. Moise KJ, Ou CN, Kirshon B, Cano LE, Rognerud C, Carpenter RJ. Placental transfer of indomethacin in the human pregnancy. Am J Obstet Gynecol. 1990;162(2):549–554
  6. Dudley DK, Hardie MJ. Fetal and neonatal effects of indomethacin used as a tocolytic agent. Am J Obstet Gynecol. 1985;151(2):181–184
  7. Meyers RL, Alpan G, Lin E, Clyman RI. Patent ductus arteriosus, indomethacin, and intestinal distension: effects on intestinal blood flow and oxygen consumption. Pediatr Res. 1991;29(6):569–574
  8. Gleason CA, Clyman RI, Heymann MA, Mauray F, Leake R, Roman C. Indomethacin and patent ductus arteriosus: effects on renal function in preterm lambs. Am J Physiol. 1988;254(1 Pt 2):F38–F44
  9. Leffler CW, Busija DW, Fletcher AM, Beasley DG, Hessler JR, Green RS. Effects of indomethacin upon cerebral hemodynamics of newborn pigs. Pediatr Res. 1985;19(11):1160–1164
  10. Amin SB, Sinkin RA, Glantz JC. Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes. Am J Obstet Gynecol. 2007;197:e1–e10
  11. Soraisham AS, Amin HJ, Al-Hindi MY, Singhal N, Sauve RS. Does necrotising enterocolitis impact the neurodevelopmental and growth outcomes in preterm infants with birthweight < or = 1250 g?. J Paediatr Child Health. 2006;42(9):499–504
  12. Rees CM, Pierro A, Eaton S. Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis. Arch Dis Child Fetal Neonatal Ed. 2007;92:F193–F198Epub 2006
  13. Resch B, Vollaard E, Maurer U, Haas J, Rosegger H, Muller W. Risk factors and determinants of neurodevelopmental outcome in cystic periventricular leucomalacia. Eur J Pediatr. 2000;159(9):663–670
  14. Salokorpi T, Eronen M, von Wendt L. Growth and development until 18 months of children exposed to tocolytics indomethacin or nylidrin. Neuropediatrics. 1996;27(4):174–177
  15. al-Alaiyan S, Seshia MM, Casiro OG. Neurodevelopmental outcome of infants exposed to indomethacin antenatally. J Perinat Med. 1996;24(4):405–411
  16. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92:529–534
  17. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis: therapeutic decisions based upon clinical staging. Ann Surg. 1978;187:1–7
  18. Redline RW, Faye-Petersen O, Heller D, Qureshi F, Savell V, Vogler C. Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol. 2003;6:435–448
  19. Vohr BR, Wright LL, Poole WK, McDonald SA. Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks' gestation between 1993 and 1998. Pediatrics. 2005;116(3):635–643
  20. Hack M, Wilson-Costello D, Friedman H, Taylor GH, Schluchter M, Fanaroff AA. Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000 g: 1992-1995. Arch Pediatr Adolesc Med. 2000;154:725–731
  21. Macones GA, Robinson CA. Is there justification for using indomethacin in preterm labor? (an analysis of neonatal risks and benefits). Am J Obstet Gynecol. 1997;177(4):819–824
  22. Gomez R, Ghezzi F, Romero R, Munoz H, Tolosa JE, Rojas I. Premature labor and intra-amniotic infection: clinical aspects and role of the cytokines in diagnosis and pathophysiology. Clin Perinatol. 1995;22(2):281–342
  23. Andrews WW, Goldenberg RL, Faye-Petersen O, Cliver S, Goepfert AR, Hauth JC. The Alabama Preterm Birth study: polymorphonuclear and mononuclear cell placental infiltrations, other markers of inflammation, and outcomes in 23- to 32-week preterm newborn infants. Am J Obstet Gynecol. 2006;195(3):803–808
  24. Bashiri A, Burstein E, Mazor M. Cerebral palsy and fetal inflammatory response syndrome: a review. J Perinat Med. 2006;34(1):5–12

 The study was performed as part of a clinical investigational training toward Masters in Clinical Research and was funded by K-23 NIH grant DC 06229.

 Cite this article as: Amin SB, Kamaluddeen M, Sangem M. Neurodevelopmental outcome of premature infants after exposure to antenatal indomethacin. Am J Obstet Gynecol 2008;199:41.e1-41.e8.

PII: S0002-9378(08)00004-5

doi: 10.1016/j.ajog.2007.12.037

American Journal of Obstetrics & Gynecology
Volume 199, Issue 1 , Pages 41.e1-41.e8 , July 2008

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