American Journal of Obstetrics & Gynecology
Volume 199, Issue 1 , Pages 62.e1-62.e6 , July 2008

First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study

  • Geralyn Lambert-Messerlian, PhD

      Affiliations

    • Warren Alpert Medical School of Brown University, Providence, RI
    • ,
  • Monica McClain, PhD

      Affiliations

    • Warren Alpert Medical School of Brown University, Providence, RI
    • ,
  • James E. Haddow, MD

      Affiliations

    • Warren Alpert Medical School of Brown University, Providence, RI
    • Corresponding Author InformationReprints: James E. Haddow, MD, Director, Division of Medical Screening, Women & Infants Hospital, 70 Elm Street, 2nd Floor, Providence, RI 02903.
    • ,
  • Glenn E. Palomaki, BS

      Affiliations

    • Warren Alpert Medical School of Brown University, Providence, RI
    • ,
  • Jacob A. Canick, PhD

      Affiliations

    • Warren Alpert Medical School of Brown University, Providence, RI
    • ,
  • Jane Cleary-Goldman, MD

      Affiliations

    • Columbia University College of Physicians and Surgeons, New York, NY
    • ,
  • Fergal D. Malone, MD

      Affiliations

    • Columbia University College of Physicians and Surgeons, New York, NY
    • Royal College of Surgeons in Ireland, Dublin, Ireland.
    • ,
  • T. Flint Porter, MD

      Affiliations

    • University of Utah and Intermountain HealthCare, Salt Lake City, UT
    • ,
  • David A. Nyberg, MD

      Affiliations

    • Swedish Medical Center, Seattle, WA
    • ,
  • Peter Bernstein, MD

      Affiliations

    • Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Mary E. D'Alton, MD

      Affiliations

    • Columbia University College of Physicians and Surgeons, New York, NY
    • ,
  • FaSTER Research Consortium

Received 24 May 2007 ,Revised 5 November 2007 ,Accepted 6 December 2007.

References 

  1. Smallridge RC, Glinoer D, Hollowell JG, Brent G. Thyroid function inside and outside of pregnancy: what do we know and what don't we know?. Thyroid. 2005;15:54–59
  2. Haddow JE, Knight GJ, Palomaki GE, McClain MR, Pulkkinen AJ. The reference range and within-person variability of thyroid stimulating hormone during the first and second trimesters of pregnancy. J Med Screen. 2004;11:170–174
  3. Dashe JS, Casey BM, Wells CE, et al. Thyroid-stimulating hormone in singleton and twin pregnancy: importance of gestational age-specific reference ranges. Obstet Gynecol. 2005;106:753–757
  4. Casey BM, Dashe JS, Spong CY, McIntire DD, Leveno KJ, Cunningham GF. Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Obstet Gynecol. 2007;109:1129–1135
  5. Malone FD, Canick JA, Ball RH, et al. First-trimester or second-trimester screening, or both, for Down's syndrome. N Engl J Med. 2005;353:2001–2011
  6. Glinoer D. The systematic screening and management of hypothyroidism and hyperthyroidism during pregnancy. Trends Endocrinol Metab. 1998;9:403–411
  7. Haddow JE, McClain MR, Palomaki GE, Hollowell JG. Urine iodine measurements, creatinine adjustment, and thyroid deficiency in an adult United States population. J Clin Endocrinol Metab. 2007;92:1019–1022
  8. Wald NJ, Cuckle H, Brock JH, Peto R, Polani PE, Woodford FP. Maternal serum-alpha-fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy (Report of U.K. collaborative study on alpha-fetoprotein in relation to neural-tube defects). Lancet. 1977;1:1323–1332
  9. Poppe K, Glinoer D. Thyroid autoimmunity and hypothyroidism before and during pregnancy. Hum Reprod Update. 2003;9:149–161
  10. Soldin OP, Tractenberg RE, Hollowell JG, Jonklaas J, Janicic N, Soldin SJ. Trimester-specific changes in maternal thyroid hormone, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency. Thyroid. 2004;14:1084–1090
  11. Allan WC, Haddow JE, Palomaki GE, et al. Maternal thyroid deficiency and pregnancy complications: implications for population screening. J Med Screen. 2000;7:127–130
  12. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999;341:549–555
  13. Vaidya B, Bilous M, Hutchinson RS, et al. Screening for thyroid disease in pregnancy: an audit. Clin Med. 2002;2:599–600
  14. Vaidya B, Anthony S, Bilous M, et al. Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding?. J Clin Endocrinol Metab. 2007;92:203–207
  15. Brent GA. Diagnosing thyroid dysfunction in pregnant women: is case finding enough?. J Clin Endocrinol Metab. 2007;92:39–41
  16. Stagnaro-Green A. Can a high-risk case-finding approach identify all women with thyroid dysfunction during pregnancy?. Nat Clin Pract Endocrinol Metab. 2007;3:216–217

 Cite this article as: Lambert-Messerlian G, McClain M, Haddow JE, et al. First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. Am J Obstet Gynecol 2008;199:62.e1-62.e6.This study was supported by grant R01 HD 38652 from the National Institutes of Health and the National Institute of Child Health and Human Development.A full list of the members of the FaSTER Research Consortium appears with the full-length version of this article at www.AJOG.org.

PII: S0002-9378(07)02267-3

doi: 10.1016/j.ajog.2007.12.003

American Journal of Obstetrics & Gynecology
Volume 199, Issue 1 , Pages 62.e1-62.e6 , July 2008

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